Relationship Between Oxidized Low Density Lipoprotein As Well As Its Lipid Ratios And Disease Activity In Rheumatoid Arthritis

Objective:The study was performed to investigate the expression level of ox-LDL and its lipid ratios in patients with RA,as the same time the association between ox-LDL and its lipid ratios and disease activity was analyzed.Methods:109 patients with RA,56 patients with other arthritis and 30 matched healthy controls were involved in the study.The subject’s demographic data,laboratory investigations and serum samples were collected.ELISA method was used to determine the concentration of ox-LDL in the serum of each participants and ox-LDL/HDL and ox-LDL/LDL for statistical analysis were calculated.Results:1.Ox-LDL in early RA group[(402.01±279.50)ng/ml]and non-early RA group were respectively higher than those in other arthritis groups and control group[[(279.82±185.20)ng/ml](216.83±117.52)vs(120.34 ± 72.55)ng/ml].Compared with non-early RA,ox-LDL concentration was higher in early RA.Similarly,ox-LDL/LDL and ox-LDL/HDL levels in early RA were higher than those in non-early RA,other arthritis groups and healthy control groups(P<0.05).2.There was statistical difference in ox-LDL level among different activity levels(F=3.780,P<0.05),but there was no statistical difference in ox-LDL/LDL and ox-LDL/HDL among different activity levels(P>0.05).3.Ox-LDL was correlated with PD score,ESR,CRP,DAS28-ESR(r=0.241,0.282,0.330,0.294,P<0.05)positively.The lipid ratios were not correlated with inflammatory markers and disease activity(P>0.05).4.It is indicated in the multivariate logistic regression analysis that ox-LDL level(OR=2.977,P=0.021)was independently correlated with RA disease activity after controlling for confounding factors.5.A total of 29 patients with RA who received lipid-lowering therapy from 2019 to 2020 were collected,ox-LDL and DAS28-ESR in RA patients were compared before and after lipid-lowering treatment,and the results indicated that ox-LDL and DAS28-ESR in RA patients were lower after lipid-lowering treatment than before(P<0.05).Δox-LDL was associated with ΔDAS28ESR positively(r=0.265,P=0.029).Conclusion:1.Serum ox-LDL and lipid ratios increase in RA.2.Ox-LDL is associated with inflammatory markers and disease activity in RA patients,but lipid ratios are not correlated with inflammatory markers or RA disease activity.3.Disease activity of patients with RA decrease after lipid-lowering therapy,which can be attributed at least in part to decrease in serum ox-LDL,which need to be validated in prospective,larger sample sizes and rigorously designed studies.