Analysis Of Related Factors Of Liver Fat Content In Patients With Type 2 Diabetic

Background:With changes in lifestyle and dietary habits,the prevalence of type 2 diabetes(T2DM)and non-alcoholic fatty liver disease(NAFLD)has been increasing year by year,and they have become a public health problem threatening human health.And the two diseases are mutually cause and effect.Coexistence can even accelerate disease progression and lead to the adverse outcome of the two diseases,which can greatly aggravate the physical,psychological and economic burden of patients.The pathological process of non-alcoholic fatty liver is reversible in the early stages of the disease.Therefore,looking for related risk factors that affect liver fat content in patients with T2DM and taking intervention measures for crisis factors is significant for the prevention,therapy and prognosis prediction of T2DM with NAFLD.Objective:This study aims to explore the risk factors that affect liver fat content in patients with T2DM,and provide a theoretical basis for the clinical prevention,therapy and prognosis of type 2 diabetes with non-alcoholic fatty liver disease.Method:The clinical data of 225 cases of T2DM who were hospitalized in our hospital from July 2020 to December 2020 were collected.Quantitative CT(QCT)was used to measure the liver fat content(LFC)of the subjects.According to the median of LFC,they were divided into two groups,the low LFC group and the the high LFC group.Compare the clinical characteristics of the two groups,analyze the correlation between liver fat content and various indicators and analyze the independent correlation factors affecting the liver fat content of T2DM by stepwise multiple regression.Result:1.Compared with the T2DM with low liver fat content group,the T2DM with high liver fat content group has a higher proportion of men,and higher levels of systolic blood pressure(SBP),diastolic blood pressure(DBP),body mass index(BMI),waist circumference(WC),Waist to hip ratio(WHR),visceral fat area(VFA),fasting blood glucose(FPG),triglycerides(TG),C-reactive protein(CRP),alanine transaminase(ALT),aspartate transaminase(AST),glutamyl Transpeptidase(GGT),and lower levels of high-density lipoprotein cholesterol(HDL-C),the difference was statistically significant(P<0.05).But between the two groups,there is no significant differences in age,diabetes course,subcutaneous fat area(SFA),glycation hemoglobin(HbAlc),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),and alkaline phosphatase(ALP)(P>0.05).2.The male T2DM patients has higher VFA and liver fat content than female T2DM,but SFA is lower than female T2DM,the difference is statistically significant(P<0.05).There is no significant difference in age,diabetes course,BMI and total abdominal fat area(TFA)of two groups,(P>0.05).3.Spearman correlation analysis result shows that the liver fat content of T2DM is positively correlated with SBP,DBP,BMI,WC,WHR,VFA,FPG,TG,ALT,ASL,GGT,CRP,and negatively correlated with HDL-C,the correlation is statistically significant(P<0.05).And there was no significant correlation between liver fat content and age,course of diabetes,SFA,HbAlc,TC,LDL-C and ALP(P>0.05).4.Multivariate stepwise regression analysis shows that VFA and FPG are independent related factors of liver fat content in T2DM patients.5.Analysis of partial correlation between liver fat content and gender in T2DM result shows that before correcting VFA,liver fat content is correlated with gender(r=0.202,P<0.05).But after correction for the effect of VFA,the relationship between liver fat content and gender has disappeared(r=0.090,P>0.05).Conclusion:1.T2DM patients with NAFLD may have more severe metabolic disorders.2.FPG and VFA are independent risk factors for hepatic lipid deposition in patients with T2DM.3.Male T2DM patients are more likely to have liver lipid deposition than females,which may be related to the difference in fat distribution of different genders.