| Objective: By investigating the incidence of four common related viral skin diseases in HIV/AIDS patients,explore their feasibility as clinical indicators for predicting and evaluating the immune status of patients.Methods: From June2019 to June 2020,there were 760 confirmed HIV/AIDS patients who were hospitalized in the AIDS Department of the Third Affiliated Hospital of Guilin Medical College.According to the inclusion criteria,64 cases were screened to meet the requirements and combined with four common types Among HIV patients with related viral skin diseases,11 cases were combined with two or more related viral skin diseases,13 cases were not clearly diagnosed as related viral skin diseases,and 0 people fell off.Analyze the types and severity of viral skin diseases,use flow cytometry to detect the CD4+ T lymphocyte count and CD8+ T lymphocyte count of 64 patients who meet the requirements,and calculate the ratio of CD4+/CD8+,and compare the relationship between the type and severity of four common types of related viral skin diseases in patients with HIV/AIDS,CD4+T lymphocyte count,CD4+T/CD8+T ratio,statistics using SPSS25.0 software,non-parametric rank sum test comparison CD4+T lymphocyte count and CD4+T/CD8+T ratio of HIV/AIDS patients with and without related viral skin diseases,CD4+T lymphocyte count and CD4+T/CD8+T ratio of the four related viral skin diseases in HIV/AIDS patients were compared in pairs,and compare the CD4+T lymphocyte count and CD4+T/CD8+T ratio of the four related viral skin diseases of HIV/AIDS patients and the four related viral skin diseases respectively;binary logistic regression analysis was performed to compare the correlation between related viral skin diseases and CD4+T lymphocyte count and CD4+T/CD8+T ratio.Results:(1)There were 760 confirmed HIV/AIDS patients,64 HIV/AIDS patients with complete data and related viral skin diseases,with a total infection rate of 9.47%;among them,34 cases of herpes simplex(infection rate of 4.47%),herpes zoster 11 cases of herpes(infection rate 1.45%),25 cases of oral hairy leukoplakia(infection rate 3.29%),7 cases of cytomegalic inclusion disease(infection rate 0.92%).(2)Patients with related viral skin diseases are divided into 20-40 years old group,40-60 years old group,and ≥60 years old group according to their age,the proportions of each group are 18.75%,37.50%,43.75%,and ≥40 years old,the proportion is as high as 81.25%,suggesting that older HIV/AIDS patients are more likely to be infected with related viral skin diseases.(3)Comparison of CD4+T lymphocyte count and CD4+T/CD8+T ratio in HIV/AIDS patients with and without related viral skin diseases,the former’s CD4+T lymphocyte count and CD4 The ratio of +T/CD8+T were smaller than the latter,and the difference between the two were statistically significant(p<0.05).(4)There were no statistically significant difference in the CD4+T lymphocyte count and CD4+T/CD8+T ratio of the four related viral skin diseases in HIV/AIDS patients(p>0.05).(5)There were no significant difference in the counts of CD4+T lymphocytes and the ratio of CD4+T/CD8+T between HIV/AIDS patients with and without herpes simplex(p>0.05).(6)There were no significant difference in the CD4+T lymphocyte count and CD4+T/CD8+T ratio between HIV/AIDS patients with and without herpes zoster(p>0.05).(7)Comparison of CD4+T lymphocyte count and CD4+T/CD8+T ratio between HIV/AIDS patients with oral hairy leukoplakia and CD4+T/CD8+T ratio,the CD4+T lymphocyte count of the former is smaller than that of the latter,and the difference between the two was statistically significant(p<0.05);there was no significant difference in the ratio of CD4+T/CD8+T between the two(p>0.05).(8)Comparison of CD4+T lymphocyte count and CD4+T/CD8+T ratio between HIV/AIDS patients with cytomegalic inclusion disease and CD4+T/CD8+T ratio,the CD4+T lymphocyte count of the former is smaller than that of the latter,and the difference between the two was statistically significant(p<0.05);there was no significant difference in the ratio of CD4+T/CD8+T between the two(p>0.05).(9)binary logistic regression analysis shows that the combination of viral skin diseases is a clinical indicator for predicting the immune status of HIV/AIDS patients.The smaller the CD4+T lymphocyte count,the more likely HIV/AIDS patients are to have related viral skin.Disease(p<0.05).Conclusions: The immune status of HIV/AIDS patients with related viral skin diseases is lower than that of those without related viral skin diseases.HIV/AIDS patients with oral mucosal leukoplakia or cytomegalic inclusion disease may be clinical indicators for evaluating and predicting the immune status of HIV/AIDS patients. |
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