| Part one Quantitative study of epicardial fat in diabetic patients with 256-slice spiral CTObjective: Quantitatively measure the epicardial adipose tissuevolume(EATV),pericardial adipose tissue volume(PATV),atrioventricular groove,interventricular groove and the right ventricular(RV)free wall epicardial adipose tissue(EAT)thickness in diabetes patientsand the control group by 256-slice spiral CT,and explore the correlation between the quantitative value of fat around the heart anddiabetics and its clinical significance.Methods:A total of 100 patients with diabetes(41 males and 59 females,with an average age of 59.98±9.06 years)and 60 patients meet the entry criteria were selected as the control group(22 males and 38 females,with an average age of 57.28±8.96 years).All patients underwent 256-slice spiral CT,EATV,PATV,atrioventricular groove,interventricular groove and the right ventricular free wall EAT thickness were measured by Cardiac function software.EAT and related parameters in the group and the control group were statistically analyzed.Results:1.Comparison of general data between the diabetics and the control group.The BMI of diabetic was larger than that of the control group(P<0.01),there was no statistical difference in age and gender between the two groups(P>0.05).2.Before and after the body surface area was standardized,there was no significant difference in right atrioventricular groove epicardial fat thickness(RAVG).EATV,PATV,left atrioventricular groove(LAVG),anterior interventricular groove(AIVG),superior interventricular groove(SIVG),inferior interventricular groove(IIVG)and the right ventricular(RV)free wall EAT thickness in the groupwere larger than those in the control group(P<0.05).3.Diabetes were divided into less than 5 years,5 to 10 years,and more than 10 years,according to the course of disease,there is no significant difference in EATV,PATV,atrioventricular groove,interventricular groove and RV free wall thickness(P>0.05).Conclusions:The epicardial and pericardial fat in diabetic patients can be objectively evaluated by 256 slice spiral CT.Compared with normal people,the volume of epicardial adipose tissue in diabetic patients is significantly increased,the latter is expected to become a sign of diabetes diagnosis and risk stratification.This study may have early warning value for diabetes with cardiovascular risk.Part two Study on the correlation between epicardial fat and gender and age in diabetic patients by 256-slice spiral CTObjective: Quantitatively measure the epicardial adipose tissue volume(EATV),pericardial adipose tissue volume(PATV),atrioven tricular groove,interventricular groove and the right ventricular free wall EAT thickness in diabetes patients by 256-slice spiral CT,and to analyze the correlation between gender and age,explore the quantitative value of fat around the heart of diabetes patients and their differences in different genders and ages.Methods:A total of 100 patients with diabetes including 41 males and59 females,with an average age of 59.98±9.06 years.All patients underwent 256-slice spiral CT.EATV,PATV,atrioventricular groove,interventricular groove and RV free wall EAT thickness were measured by Cardiac function software.According to gender and age grouping and statistical analysis.Results:1.Comparison of clinical data between men and women in the diabetes group,there was no significant difference in clinical biochemical indicators between men and women(P>0.05).2.The AIVG,SIVG,IIVG and RV free wall EAT thickness were larger in women than in men(P<0.05),there were no significant differences in EATV,PATV,RAVG and LAVG epicardial fat thickness(P>0.05).3.After the body surface area was standardized,EATV,PATV,atrioventricular groove,interventricular groove and RV free wall EAT thickness were larger in women than in men(P<0.05).4.Comparison of epicardial fat and quantitative parameters in different age groups after body surface area standardization in diabetes mellitus group,50-59 years old,≥60 years old,EATV,PATV,LAVG,RAVG and RV free wall EAT thickness were larger than that of diabetic patients ≤50 years old.≥60 years old,AIVG and SIVG were larger than those of diabetic patients ≤50 years old(P<0.05).Conclusions:The epicardial and pericardial fat can be objectively evaluated by256 slice spiral CT.Diabetic patients of different ages and genders have different degrees of increase in EAT,when assessing the cardiovascular risk of diabetes,attention should be paid to the patient’s gender and age.The quantitative value of EAT may play an important role in predicting cardiovascular risk.Part three quantitative study of epicardial fat in diabetic patients with atrial fibrillation with 256-slice spiral CTObjective: Quantitatively measure the epicardial adipose tissue volume(EATV),Pericardial adipose tissue volume(PATV),atrioven tricular groove,interventricular groove and the right ventricular free wall EAT thickness in diabetes with atrial fibrillation by 256-slice spiral CT,explore the correlation between the quantitative value of fat around the heart and diabetes with atrial fibrillation.Methods:A total of 78 patients with diabetes(32 males and 46 females,with an average age of 60.95±9.18 years),65 diabetes patients with atrial fibrillation(35 males and 30 females,with an average age of 62.56±8.99years),30 patients with atrial fibrillation(18 males and 12 females,with an average age of 57.80±10.59 years)and 60 patients meet the entry criteria were selected as the control group(22 males and 38 females,with an average age of 57.28±8.96 years).All patients underwent 256-slice spiral CT,EATV,PATV,atrioventricular groove,interventricular groove and the right ventricular free wall EAT thickness were measured by cardiac function software.Epicardial fat and related parameters in the diabetic group,diabetic with atrial fibrillation group,atrial fibrillation group and the control group were statistically analyzed.Results:1.Comparison of general clinical data between the diabetes and the diabetes with atrial fibrillation group.there was no significal difference in clinical data between the two groups(P>0.05).2.After the body surface area is standardized,atrial fibrillation group,diabetes group,diabetes with atrial fibrillation group EATV,PATV,LAVG,AIVG epicardial fat thickness were increased compared with the control group;the thickness of the epicardial fat in LAVG and AIVG in the diabetic with atrial fibrillation group were increased compared with the diabetic group,atrial fibrillation group and the control group(P<0.001).3.Multivariate logistic regression analysis indicated that the thickness of the LAVG associated with diabetes with atrial fibrillation(OR=1.259,95% CI: 1.094-1.449,P=0.001).Conclusions:Quantification of EAT is a risk factor for assessing the risk of diabetic cardiovascular events and atrial fibrillation,increased epicardial fat thickness in the left atrioventricular groove is associated with diabetes with atrial fibrillation,and may have certain clinical value in predicting the occurrence of diabetes with atrial fibrillation. |
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