Comparative Study Of Biological Patch And Self-fixing Patch On Postoperative Inflammatory Response Of Inguinal Hernia Repair

Objective: Compare biological patch and polypropylene self-fixing patch for the postoperative inflammatory response of patients with open inguinal hernia.Methods: Using a randomized controlled study method,the collected cases were randomly divided into a control group and an experimental group.The control group used polypropylene self-fixing patch for open inguinal hernia repair.The experimental group used pig small intestinal submucosa-derived biological patch for open inguinal hernia repair.Both groups used Lichtenstein hernia repair.Peripheral blood was collected 1 day before the operation and 1 day,3 days,and 3 months after the operation.The white blood cell count,the ratio of neutrophils,interleukin-6 and white blood cells were measured.Interleukin-8,tumor necrosis factor,and hypersensitivity c-reactive protein were observed and compared.Results: The white blood cell count,neutrophil ratio,and hypersensitive c-reactive protein in the experimental group were significantly higher than those in the control group on the first day,and the difference was statistically significant.The remaining detection indicators were not statistically different.After the 3rd day,there was no statistical difference in the indicators between the two groups.Conclusion: 1.The inflammatory reaction caused by the biological patch in the early stage is stronger than that of the self-fixing patch,but it is self-limiting;2.The long-term inflammatory reaction caused by the biological patch is not higher than that of the self-fixing patch.