Clinical Study On The Treatment Of Cognitive Dysfunction In Cerebral Small Vascular Disease By Clearing Turbidity And Enriching Marrow

Objective:This study was designed to evaluate the treatment of cerebral small vascular cognitive impairment,which was based on the Chinese traditional theory.We expected that the treatment we chose could improve the life quality of patients by postponing the development of cerebral small vascular cognitive impairment.And data could be provided via the investigation of some items for the study of correlative factors of the disease.And the Chinese traditional theories would be enriched especially the theory of blood turbidity that based on the study of the pathologic process of blood turbidity damaging marrow,and so that to provide the clinical evidence for the theory of blood turbidity damaging marrow.Methods:72 patients were involved in the study,and were randomly divided into conventional treatment group and Huazhuo-yisui group,with 36 patients in each group.Both of the patients in the two groups were accepted the basic medicine treatment,and patients in Huazhuo-yisui group also accepted Huazhuo-yisui formula.The safety,the efficacy as well as the mechanism of the two therapies were evaluated and tested at the corresponding time point(before the treatment,14 days after the treatment,90 days after the treatment,respectively).Results:69 cases were observed,including 35 cases in conventional treatment group and 34 cases in Huazhuo-yisui group.There was no significant difference between the two groups in age,gender,education years,past history,history of smoking and drinking,and the distribution of syndromes,indicating a good comparability between the two groups.The differences were statistically significant in conventional treatment group between the time point of 14 d and 90 d in NIHSS,Barthel,IADL,HAMD,MMSE,MoCA and Quantitative table of TCM syndromes respectively,so did that in Huazhuo-yisui group.And for HAMD and Quantitative table of TCM syndromes,the differences were statistically significant between the time point of 0 d and 14 d in both groups.The difference was statistically significant in the two groups at the time point of 90 d,respectively,for MMSE and MoCA.There was no significant difference in the two groups at three time points for the items of APTT,PT,TT,FB,DD2 and HDL.The differences were statistically significant within the time point of 0 d and 90 d of the items of LDL,TC,lipoprotein-α,UA、SOD and Hcy respectively.In addition to Hcy,the differences were statistically significant within the two groups at the time point of 90 d.Conclusion:Marrow injury that caused by blood turbidity is an important pathological process of cerebral small vascular cognitive impairment.Therefore,Huazhuo-yisui formula was applied in this study as the treatment of CSVCI patients that possessed the pathological process above.The results showed that,the efficacy of the two groups was quite the same for the recovery of neurological function.And for cognitive function and some blood indicators,the therapy that plus Huazhuo-yisui formula was superior to the therapy used basic medicine alone.However,both of the two therapies had a small impact on liver and kidney function,so the application is safe.The results suggested that for patients with CSVCI who were identified as blood turbidity injury to marrow syndrome,Huazhuo-yisui formula could improve neurological function,cognitive function and related biochemical indexes,and elevate the life quality of the patients.