| Purpose: By the clinical investigation of Chronic Glomerulonephritis(CGN)patients,the distribution characteristics of TCM syndrome types and the relationship between TCM syndrome types and the relevant laboratory indicators are analyzed.It is expected to provide the evidence for the standardization research of TCM syndrome in CGN,and improve the accuracy of TCM syndrome differentiation of this disease.Method: The "Table of Investigation on Patients with Chronic Glomerulonephritis" is formulated,and 191 CGN patients who meet the inclusion criteria are collected by a cross-sectional survey of clinical epidemiology.Patients with CGN are classified according to syndrome differentiation.The distribution law of TCM syndrome types of this disease is explored.The correlations between TCM syndrome types and basic data such as age,gender,BMI,blood pressure classification,course of disease,and CKD stage are studied.And the relationships between TCM syndrome types and laboratory indexes such as serum creatinine,serum uric acid,serum albumin,blood lipid,urine occult blood and 24-hour urine protein quantification are researched.Result: 1.Analysis of basic data:(1)Among 191 CGN patients,87 are males and104 are females.The age distribution is mostly between 31 and 50 years old,accounting for 50.79%.(2)The proportion of CGN patients with mainly mental work is 40.84%,and that of CGN patients with mainly physical work is kidney qi deficiency syndrome.And patients without the deficiency syndrome is more common in dampness heat syndrome.4.TCM syndrome types and basic information:(1)There is no significant difference in the distribution of CGN syndrome types between different genders,age groups and disease courses(all P>0.05).(2)The BMI values of spleen and kidney qi deficiency syndrome are higher than those of liver and kidney yin deficiency syndrome(P<0.05).And the BMI values of dampness turbidity syndrome are higher than those of blood stasis syndrome(P<0.05).(3)There is a significant difference in blood pressure classification of the deficiency syndrome(P<0.05).The proportion of hypertension with liver and kidney yin deficiency syndrome is the largest,and the proportion of hypertension with qi and yin deficiency syndrome is the smallest.(4)There is a significant difference in the distribution of the standard syndrome among the patients with different CKD stages(P<0.01).The number of patients with dampness heat syndrome and non-standard syndrome in CKD1 period is relatively large,while the number of patients with water dampness syndrome as well as dampness turbid and blood stasis syndrome in CKD2 period is relatively small.5.TCM syndrome types and laboratory indicators:(1)There are significant differences in serum creatinine and serum uric acid levels among the standard syndrome types(both P<0.01).The serum creatinine levels of dampness turbid and blood stasis syndrome,dampness turbid syndrome,dampness heat and blood stasis syndrome as well as blood stasis syndrome are higher.The blood uric acid levels of dampness turbid and blood stasis syndrome,dampness heat and blood stasis syndrome as well as dampness turbid syndrome is higher.(2)The total cholesterol level of spleen and kidney qi deficiency syndrome is higher than that of qi and yin deficiency syndrome(P<0.05),and that of dampness turbid syndrome is higher than that of water dampness syndrome(P<0.05).(3)There are significant differences in the severity of urinary occult blood between water dampness syndrome and dampness heat 35.60%.They are evenly distributed.(3)The majority of those who are partial to diet are 63.87%,and most of them are fat preference,greasy preference and spicy preference.(4)The highest incidence is in spring,followed by winter,summer and autumn.(5)The incidence of fatigue and infection accounts for a high proportion of 21.99% and 21.47%,respectively.(6)Proportion of complicated diseases: hypertension> hyperlipidemia> others> hyperuricemia>diabetes.2.Symptoms,tongue and pulse distribution:(1)Symptoms: The symptoms with more than 10% frequency are fatigue,foam in urine,lumbar spine pain,nocturnal urine,fecal failure,edema of both lower limbs,anorexia,dizziness or headache,easy to catch a cold,dry mouth,poor sleep,low back tingling or pain fixation,facialedema,dry eyes or blurred vision,hot hand and foot,low back pain,chest tightness and complexion shaohua.(2)Tongue image: The tongues with more than 10% frequency are red,light red and dark red;The tongue coatings with more than 10% frequency are thin white,thin yellow greasy,white greasy,yellow greasy and thin white greasy.(3)Pulse image: The pulses with more than 10% frequency are heavy fine vein and sunken pulse.3.Distribution of TCM syndrome types:(1)The deficiency syndrome: spleen and kidney qi deficiency syndrome> qi and yin deficiency syndrome> liver and kidney yin deficiency syndrome> lung and kidney qi deficiency syndrome> spleen and kidney yang deficiency syndrome.(2)The standard syndrome: dampness heat syndrome> blood stasis syndrome> water dampness syndrome> dampness turbid syndrome> dampness heat and blood stasis syndrome> dampness turbid and blood stasis syndrome.(3)Mixed syndrome: Spleen and kidney qi deficiency syndrome is mostly combined with dampness heat syndrome and water dampness syndrome.Spleen and kidney yang deficiency syndrome is mostly combined with water dampness syndrome.Liver and kidney yin deficiency syndrome as well as qi and yin deficiency syndrome are mostly combined with dampness heat syndrome.Patients without the standard syndrome is more common in spleen and syndrome,dampness heat and blood stasis syndrome(both P<0.05).Dampness heat syndrome as well as dampness heat and blood stasis syndrome are more obvious.(4)The quantitative level of 24-hour urine protein of spleen and kidney yang deficiency syndrome is higher than that of liver and kidney yin deficiency syndrome(P<0.05).Conclusion: 1.In this study,female patients of CGN account for a higher proportion than male patients.Young and middle-aged are susceptible.This disease is more likely to occur in spring,summer and winter.Fatigue and infection are the most common causes of this disease.People who prefer to eat fatty food and spicy food may be more susceptible to this disease.2.For the deficiency syndrome of this disease,spleen and kidney qi deficiency syndrome is more common.And for the standard syndrome,dampness heat syndrome is more common.There is a certain correlation between BMI values and the distribution of TCM syndrome types of this disease.The BMI values of spleen and kidney qi deficiency syndrome and dampness turbid syndrome are higher.There is a correlation between the blood pressure grade and the distribution of the deficiency syndrome types.The blood pressure control of liver and kidney yin deficiency syndrome is not ideal.There is a correlation between the CKD stage and the distribution of the standard syndrome types.In CKD1 period,dampness heat syndrome and non-standard syndrome are common,while in CKD2 period,water dampness syndrome as well as dampness turbid and blood stasis syndrome are rare.3.The serum creatinine and uric acid levels are correlated with the distribution of the standard syndrome types.The kidney function damage of dampness turbid and blood stasis syndrome,dampness turbid syndrome,dampness heat and blood stasis syndrome are more obvious.There is a correlation between the total cholesterol level and the distribution of TCM syndrome types of this disease.The levels of total cholesterol in spleen and kidney qi deficiency syndrome and dampness turbid syndrome are higher.The severity of urinary occult blood is correlated with the distribution of the standard syndrome types.The urine occult blood of dampness heat syndrome as well as dampness heat and blood stasis syndrome is more obvious.There is a correlation between the quantitative level of 24-hour urine protein and the distribution of the deficiency syndrome types.The urine protein of spleen and kidney yang deficiency syndrome is more obvious. |
