| ObjectiveTo observe and explore the relationship between the changes of serum macrophage stimulating protein levels and the improvement of lung function after Doxofylline used in the treatment of AECOPD patients.MethodA total of 69 AECOPD patients who were hospitalized in this hospital from 2019 to 2020 were selected and randomly divided into a control group of 33 cases and an observation group of 36 cases according to the calendar single number as the control group and the double number as the observation group.Before drug treatment was given to the patients pulmonary ventilation function was detected,venous blood was used to detect CRP and PCT and other biochemical indicators,and arterial blood was used to detect arterial blood gas.After that,the control group was given symptomatic treatments such as routine controlled oxygen therapy,anti-infection,phlegm,and asthma.The control group was treated with Doxofylline(300 mg qd intravenous infusion).After 7 days of treatment,the above method was used to detect lung ventilation function,CRP,PCT and arterial blood gas again.The double antibody sandwich ELISA method was used to detect the level of MSP in the control group and observation group before and after treatment during hospitalization.SPSS 24.0 was used for analysis and mapping.The variables of all measurement data were expressed as mean±standard deviation(?x±s).Paired t test was used before and after treatment in the same group,and independent samples were used before and after treatment between the two groups.t test.All count data are tested with ?2,P<0.05 was considered statistically different.Result1.Baseline characteristics(Table 1): gender(P=0.983),age(70.70±9.25 years vs.73.76±7.53 years,P=0.138),BMI(23.89±4.09 vs.22.65±4.04,P= 0.255)and APACHEⅡ score(14.94±0.24 vs.15.12±0.22,P=0.588),there was no statistical difference(P>0.05).2.Before treatment(Table 1): MSP,clinical symptom score,FVC% predicted value,FEV1% predicted value,PEF% predicted value,PH,Pa CO2,Pa O2,CRP and PCT were not statistically compared between the observation group and the control group Difference(P>0.05).3.After treatment(Table 2): MSP of observation group and control group(4.22±1.16 vs.5.06±1.00,P=0.002),clinical symptom score(1.38±0.08 vs.2.92±0.03,P<0.001),FVC% predicted value(67.59±13.71 vs.59.38±12.95,P=0.015),FEV1%predicted value(54.12±16.9 vs.45.41±12.6,P=0.018),PEF% predicted value(52.13±1.35 vs.43.69±1.16,P<0.001),PH(7.36±0.02 vs.7.43±0.01,P<0.001),Pa CO2(38.51±2.29 vs.41.52±1.12,P=0.001),CRP(7.86±0.02 vs.9.36±0.13,P<0.001)and PCT(0.032±0.003 vs.0.062±0.001,P<0.001),and there were statistically significant differences(P<0.05).The Pa O2 of the observation group and the control group(84.96±15.04 vs.82.67±14.45,P=0.71)was not statistically different(P>0.05),but the Pa O2 of the observation group was 2.8% higher than that of the control group.4.The total effective rate after treatment(Table 3): The observation group is3.28% higher than the control group(97.22% vs.93.94%),which is statistically significant(P<0.05)5.Correlation analysis between MSP and pulmonary ventilation function(FVC%pred,FEV1% pred,PEF% pred),clinical symptom score,CRP,PCT and arterial blood gas analysis(PH,Pa CO2,Pa O2)in AECOPD patients(Table 4): MSP is negatively correlated with FVC% pred,FEV1% pred and PH(P<0.05),positively correlated with clinical symptom score,PCT,Pa CO2(P<0.05),and has no correlation with PEF% pred,Pa O2 and CRP(P >0.05).ConclusionThe effect of Doxofylline in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease is more significant than that of conventional controlled oxygen therapy,anti-infection,phlegm,and asthma,and can improve the level of MSP,pulmonary ventilation and treatment The total effective rate,clinical symptom score,CRP and PCT. |
