Expression And Significance Of SOX11 In Oral Squamous Cell Carcinoma

Background:Oral squamous cell carcinoma is the most common type of oral cancer,accounting for about 90%.Due to its early and widespread metastasis,it has become one of the causes of death that cannot be ignored in China.Now its pathogenesis is unclear,but bad habits such as smoking and drinking alcohol are risk factors for the disease.Other factors include HPV infection,betel nut chewing,and immune deficiency.Due to the special location of oral cancer,the vast majority of cases will affect the swallowing and chewing ability and affect the appearance of the patients,which will result in serious damage to the quality of life and mental health of patients.At present,the treatment method is still based on radical surgical resection of tumor combining with comprehensive sequence therapy.However,as most patients are unable to receive early diagnosis and treatment,their 5-year survival rate is still low,at only 50%-70%.Therefore,early diagnosis of oral squamous cell carcinoma is very important for clinical treatment and patient prognosis.SOX family was first discovered due to its highly conserved and similar high mobility groups.Early studies mainly focused on the role of SOX family on embryo development and tissue differentiation.With the publication of a large number of research results on SOX family,researchers gradually found that it plays an important role in cancer treatment.Many members of the SOX family have been reported to be related to the occurrence and development of oral squamous cell carcinoma,such as SOX4,SOX2 and SOX8,which can promote the occurrence and development of oral squamous cell carcinoma by regulating related pathways and downstream factors,while SOX7 can play a role as a tumor suppressor in oral squamous cell carcinoma.SOX11 is an important member of SOX C group of transcription factors,which regulates nerve differentiation,bone growth and other important processes during early embryonic development.SOX11 has also been extensively studied in cancers,such as its specific high expression in mantle cell lymphoma,which has been confirmed to be a reliable diagnostic marker in such kind of cancer.In epithelial ovarian cancer,SOX11 expression was significantly upgraded in tumor tissues compared with normal tissues.In addition,SOX11 can also be used as a tumor suppressor.Studies have shown that SOX11 can inhibit the metastasis and invasion of gastric cancer cells in vivo and in vitro,and it can also be used as a prognostic marker for a subgroup of gastric cancer.However,there are few studies on the expression of SOX11 in oral squamous cell carcinoma,and there are some differences in conclusions.Objective:To detect the expression of SOX11 in oral squamous cell carcinoma and normal oral mucosal tissues,to explore the significance of SOX11 expression in oral squamous cell carcinoma,to discuss the role of SOX11 in the occurrence and development of oral squamous cell carcinoma,and to speculate the role of SOX11 in the diagnosis of oral squamous cell carcinoma.Methods:To select 43 cases of patients with oral squamous cell carcinomas who didn’ t accept prior hormonal therapy and chemotherapy and are the first surgical and 10 cases of normal oral mucosa tissues,to carry out the experiment by HE staining and immunohistochemical staining method,to test SOX11 in oral squamous carcinoma tissues and the expression level of normal oral mucosa tissues,to use t test and nonparametric rank SOX11 protein expression to measure and test the differences in different tissue types and different clinical pathological parameters tissues.All the results with P < 0.05 statistically difference.Results:1.Compared with normal mucosal tissues,the expression of SOX11 in oral squamous cell carcinoma was significantly up-regulated(P<0.001).2.There was no significant difference in SOX11 expression among tumor tissues with different clinicopathological parameters(P>0.05).Conclusion:The expression of SOX11 in tumor tissues was significantly up-regulated than that in normal tissues,which confirmed that the abnormal expression of SOX11 in oral squamous cell carcinoma may be involved in the pathogenesis of oral squamous cell carcinoma and may be used as a marker for early diagnosis of oral squamous cell carcinoma.