Relationship Between Preoperative Neutrophilic Lymphocyte Ratio,Platelet Lymphocyte Ratio And Postoperative Microvascular Infiltration In Patients With Primary Hepatocellular Carcinoma

Objective: To explore the relationship between preoperative neutrophil lymphocyte ratio(NLR),platelet lymphocyte ratio(PLR)and postoperative microvascular infiltration(MVI)in patients with primary hepatocellular carcinoma(HCC).Methods: The clinical data of 224 HCC patients who underwent radical resection and confirmed by postoperative pathology in our hospital from January 2016 to December 2019 were retrospectively analyzed.The data about the patients’ gender,age,height,body mass index(BMI),and the tumor diameter,tumor site,postoperative pathological type,as well as the neutrophil count,lymphocyte count,alpha-fetal protein(AFP),glutamic-oxalacetic transaminase(AST),alanine aminotransferase(ALT),microvascular infiltration(MVI),TNM stage and other relevant data were counted.Meanwhile,according to the postoperative pathological diagnosis,the patients were divided into MVI negative group and MVI positive group.The differences of NLR and PLR between the two groups were compared.The relationship between NLR,PLR and MVI was analyzed by multivariate logistic regression model.Then,we counted the survival time and state of the patients,and analyzed the correlations between the NLR,PLR,and main clinicopathological parameters and the prognosis of patients with CRC.Results: Univariate analysis showed that there were significant differences in NLR,PLR,preoperative AFP,preoperative alt,tumor size and tumor differentiation between MVI positive and MVI negative groups(all P < 0.05),while there was no significant difference in AST and TNM clinical stages between the two groups(all P > 0.05).Multivariate logistic regression analysis showed that NLR(≥ 1.95 / < 1.95),preoperative AFP(>400μg/L / ≤400μg/L)and tumor differentiation(poorly differentiated / well differentiated)were independent risk factors for microvascular infiltration(MVI)in HCC patients,with or values of 2.289,3.111 and 1.363,respectively.Survival analysis showed that NLR,AFP,tumor size and TNM stage were risk factors for poor prognosis of HCC patients,and subgroup analysis showed that NLR had good predictive value for prognosis of HCC patients.Conclusion: The levels of NLR and AFP in the HCC patients’ peripheral blood are expected to be a simple,economic and convenient predictor for predicting the presence of postoperative MVI.Besides,NLR and AFP are risk factors for poor prognosis in HCC patients,which can provide reference for the selection of treatment plan in clinical diagnosis and treatment of HCC.