Clinical Observation Of Qihuang Yangwei Decoction On Chronic Atrophic Gastritis With Dampness-heat Caused By Spleen Deficiency

Objective:To observe the clinical effect of Qihuang Yangwei Decoction on chronic atrophic gastritis with dampness-heat caused by spleen deficiency.Methods:Sixty patients with dampness-heat type CAG of spleen deficiency were randomly selected,among which the study group was Qihuang Yangwei Decoction group(30 cases),and the control group was Weifuchun group(30 cases).Both groups were treated continuously for a course of treatment.The scores of TCM syndrome,gastroscopy and pathological tissue before and after treatment were observed and compared between the two groups.Results:1.Clinical efficacy analysis of the two groups:after treatment,the total effective rate of Qihuang Yangwei Decoction group was 96.7%,the total effective rate of Weifuchun group was 86.3%;Compared with other groups,the therapeutic effect of Qihuang Yangwei Decoction group was more outstanding(P<0.05).2.Comparison of total scores of TCM syndromes between the two groups:after treatment,intra-group comparison showed that the two groups had overall improvement in TCM syndromes(P<0.05);Comparison between groups indicated that the treatment effect of Qihuang Yangwei Decoction group was more prominent(P=0.001<0.05).3.Comparison of scores of major TCM symptoms between the two groups:after treatment,intra-group comparison showed that the main symptoms of epigastric and abdominal fullness,faint stomachache,body fatigue and fatigue were relieved compared with those before(P<0.05);Compared with other groups,Qihuang Yangwei Decoction had more obvious effects on improving epigastric puffiness and stomachache(P<0.05).There was no significant difference between the two groups in improving body fatigue(P>0.05).4.Comparison of scores of minor TCM symptoms between the two groups:among the groups,loose stools,lack of food and absorption,dry mouth and bitter mouth,lukewarm limbs and drowsiness of limbs were all improved(P<0.05);Compared with the other two groups,Qihuang Yangwei Decoction had a more prominent effect in improving the lack of food and tolerance,dry mouth and bitter mouth,and drowsiness of limbs(P<0.05),but there was no obvious effect in the two groups of loose stools and warm limbs(P>0.05).5.Comparison of endoscopic total score:intra-group comparison showed that mucosal lesions under endoscopy were significantly improved compared with those before treatment(P<0.05);Compared with groups,Qihuang Yangwei Decoction improved mucosa better than Weifuchun(P<0.05).6.The score of major pathological changes under gastroscopy:the rough mucosa,vascular exposure and granular nodules were improved within the group compared with before treatment(P<0.05);Compared with the two groups,Qihuang Yangwei Decoction had a more prominent effect in improving the rough mucosa and vascular exposure(P<0.05),and there was no significant difference in drug efficacy between the two groups(P>0.05).7.The next lesion score of gastroscopy:intra-group comparison showed that drugs in both groups could improve mucosal erosion,mucosal erythema,bile reflux and other pathological changes(P<0.05);Compared with other groups,Qihuang Yangwei Decoction had more prominent effect in improving mucosal erosion and bile reflux(P<0.05),while there was no significant difference in improving mucosal erythema between the two groups(P>0.05).8.Comparison of pathological scores:intra-group comparison showed that pathological scores in both groups were improved(P<0.05);Compared with other groups,Qihuang Yangwei Decoction had better curative effect(P<0.05).9.Comparison of main pathological scores:intra-group comparison showed that atrophy,intestinal metaplasia,intraepithelial neoplasia,active inflammation and other pathological changes were improved in both groups to some extent(P<0.05);The improvement of atrophy and intestinal metaplasia in the treatment group was better than that in the control group(P<0.05),and there was no significant difference in the improvement of intraepithelial neoplasia and active inflammation between the two groups(P>0.05).10.There were no abnormal manifestations in the two groups during treatment.Conclusion:In general,Qihuang Yangwei Decoction has more outstanding efficacy in treating dampness-heat type CAG with spleen deficiency,significantly alleviating clinical symptoms,improving pathological changes of mucosa and reducing inflammatory reaction,which is worthy of clinical promotion and application.