Correlation Between Distribution Of TCM Syndromes Of Chronic Atrophic Gastritis And Microscopic Manifestations,Pathology,Kimura-Takemoto Classification

1 PurposeBy investigating the distribution characteristics of TCM syndrome type of chronic atrophic gastritis(CAG),this paper discusses the correlation between TCM syndrome type of chronic atrophic gastritis and endoscopic manifestations,pathological characteristics,Kimura-Takemoto classification,provides some microscopic and objective reference basis for diagnosis,treatment and prognosis judgment of chronic atrophic gastritis.2 MethodsAccording to the inclusion and exclusion criteria of this study,patients enrolled in the outpatient department or inpatient department of the Affiliated Hospital of Chengdu University of Chinese Medicine from November 2019 to January 2021,clearly diagnosed as chronic atrophic gastritis through gastroscopy and pathhistological examination,Collecting general data,four diagnosis information,traditional Chinese medicine syndrome,gastroscopy performance,pathological histology description etc.using descriptive analysis,differential test and other statistical methods,to explore the characteristics of TCM syndrome type distribution of chronic atrophic gastritis,the correlation of TCM syndrome type and endoscopic manifestations,pathological histological manifestations,and the classification of Kimura-Takemoto.3 Result3.1 General information:(1)the study included exclusion criteria,In 155 patients,Of these,87 were males(56.13%),68 women(43.87%),Upon examination,There was no significant correlation between CAG incidence and sex(P>0.05).(2)The majority of ethnic groups were Han(87.74%).(3)Age distribution in the study was 26-81 years old,with an average age of 56.942±10.923 years old and over 50years old,accounting for 76.13%.(4)The proportion of risk factors leading to CAG in the cohort:HP infection>smoking,alcohol consumption>emotional factors>diet partial hobby>history of cholecystectomy>nonsteroidal drug use,family history of gastric cancer.3.2 Distribution of TCM syndrome types:Of the 155 CAG patients included in this study,there were 16 TCM syndrome types,the common syndromes are spleen and stomach weakness syndrome,liver and stomach stagnation heat syndrome,spleen deficiency dampness-heat syndrome,syndrome of stagnation of liver qi and spleen deficiency,spleen and stomach dampness-heat syndrome,liver stagnation spleen deficiency dampness-heat syndrome.3.3 Correlation between TCM syndrome type and endoscopic findings:155patients CAG the most common endoscopic findings were:mainly white phase,depression in white area,pattern change,mucosal thinning,mucosal roughness,vascular exposure,bile reflux,erosion,congestion,old bleeding distribution in different syndromes,All the differences were not statistically significant(P>0.05).Comparison of the ratio of"granular or nodular"in different syndromes,difference was statistically significant(P<0.05);Showing bile reflux,It is more common in the liver-depression group than in the non liver-depression group,But by comparison,χ~2=1.688,P=0.194,there was no significant difference between the two groups(P>0.05).3.4 Correlation between TCM syndrome type and pathological manifestations:There was no significant difference in the inflammatory distribution of different TCM syndromes among 155 CAG patients(P>0.05),and there was significant difference in the activity,atrophy,intestinal metaplasia,epithelial neoplasia distribution among the different syndromes(P>0.05).The degree of atrophy and epithelial neoplasia distributionin the blood stasis syndrome group were significantly higher than those in the non-blood stasis syndrome group.3.5 Correlation between TCM syndrome type and Kimura-Takemoto classification:The correlation between different TCM syndromes and Kimura-Takemoto Classification,Z=23.532,P=0.073,(P>0.05),It is suggested that there is no correlation between TCM syndrome type and Kimura-Takemoto classification.4 Conclusion4.1 The incidence of chronic atrophic gastritis in this study was not related to sex,but correlated with age.4.4 Risk factors for chronic atrophic gastritis:HP infection>smoking,alcohol consumption>emotional factors>diet partial hobby>history of cholecystectomy>nonsteroidal drug use,family history of gastric cancer.4.3 In this study,there was no correlation between different TCM syndromes and gastroscopy.4.4 CAG TCM syndromes are correlated with inflammatory activity,atrophy,intestinal metaplasia and epithelial neoplasia distributionin.4.5 In this study,there was no correlation between CAG different TCM syndromes and Kimura-Takemoto classification.4.6 Traditional Chinese medicine(TCM)has some consistency with the progress of CAG course,microscopic manifestation and pathology according to the four diagnosis information,so it can be used as a complementary means of diagnosis and treatment to some extent.