Correlation Of Peripheral Blood Indexes With Hepatitis C Cirrhosis Complicated With Upper Gastrointestinal Bleeding

Objective: To investigate the clinical value of platelet-lymphocyte ratio(PLR),neutrophil-lymphocyte ratio(NLR),red blood cell volume distribution width(RDW)and aspartate aminotransferase-to-platelet ratio(APRI)in evaluating the risk of patients with hepatitis C cirrhosis complicated with upper gastrointestinal bleeding.Methods: Retrospective analysis of clinical data and laboratory results(blood routine,biochemical examination and coagulation time)of 69 patients with hepatitis C cirrhosis complicated with upper gastrointestinal bleeding(Gastrointestinal bleeding group)and 110 patients with hepatitis C cirrhosis without upper gastrointestinal bleeding(Non-gastrointestinal bleeding group)hospitalized for the first time in the affiliated Hospital of Yanbian University from January2015 to October 2020 and PLR,NLR and APRI were calculated.The independent risk factors of hepatitis C cirrhosis complicated with upper gastrointestinal bleeding were analyzed by Logistic regression method,and the clinical significance of each index were evaluated by the Roc curve analysis.Results:1.The results of univariate analysis showed that there were significant differences in RDW,ALB,PT,PT%,INR,MELD,NLR,LMR,PLR,ALBI and APRI between gastrointestinal bleeding group and non-bleeding group(P <0.05).There was no significant difference in APTT,FIB-4,AAR and RPR(P >0.05).2.Multivariate Logistic regression analysis showed that PLR,NLR,RDW and APRI were independent risk factors of hepatitis C cirrhosis complicated with upper gastrointestinal bleeding(P <0.05).3.PLR,RDW were correlated with Child-Pugh score(P <0.05),their correlation coefficients were-0.155 and 0.263,PLR,NLR,RDW,APRI were correlated with MELD score(P <0.05),their correlation coefficients were-0.231、0.182、0.277 and 0.15.4.The value of evaluating the risk of upper gastrointestinal bleeding in patients with hepatitis C cirrhosis:The areas under the ROC curve of PLR,NLR,RDW and APRI were 0.867,0.756,0.667 and 0.650,the sensitivity were 85.51,82.61,69.57,75.36,and the specificity were 79.09,63.64,56.36,50.91.The diagnostic value of PLR is superior to other indexes.Conclusion:PLR,NLR,RDW and APRI can indicate the risk of patients with hepatitis C cirrhosis complicated with upper gastrointestinal bleeding.PLR is of high predictive value in patients with hepatitis C cirrhosis complicated with upper gastrointestinal bleeding.