The Clinical Study Of Modified Painless Purulent Moxibustion With Wheat Grain In Treatment Of Cough Variant Asthma

Objective: To observe and compare the short-term(after treatment)and long-term(after 3 months)clinical efficacy of Modified Painless Purulent Moxibustion With Wheat Grain combined with budesonide and formoterol powder inhalation and single inhalation in the treatment of Cough Variant Asthma(wind-cold evil hides in lung).And analyzed preliminarily the mechanism of action.To introduce a kind of TCM external treatment method with better application and popularization for clinical treatment.Methods: A total of 60 patients with CVA were randomly divided into two groups.The control group of 30 cases were treated with budesonide and formoterol powder inhalation,while the observation group of 30 cases were treated with Modified Painless Purulent Moxibustion With Wheat Grain at Feishu,Gaohuang and Zusanli on the basis of treatment of control group;Both groups were treated for 8 weeks.The cough score,TCM syndrome score and VAS score of the subjects were observed and compared in the before,after and 3 months of treatment;the values of FEV1 and PEF of lung function were observed and compared before and after treatment;the clinical efficacy of the two groups was evaluated and compared after treatment and 3 months of follow-up.SPSS22.0 statistical software was used for data analysis.Results:1.Cough score,TCM syndrome score and VAS score: Intra-group comparison showed that the cough score,TCM syndrome score and VAS score after treatment and 3 months of treatment in both groups were lower than those before treatment(P<0.05);Compared with the control group,the cough score,TCM syndrome score and VAS score in the observation group after treatment and 3 months of treatment were decreased more significantly(P<0.05).2.Lung function indexes: Intra-group comparison showed that FEV1 and PEF values of after treatment of the two groups were higher than before(P<0.05);FEV1 and PEF values of after treatment of the observation group were both higher than the control group(P<0.05).3.Clinical efficacy: The total effective rate of after treatment of the observation group was 92.86%,while control group was 77.78%;the total effective rate of 3 months of treatment of the observation group was 89.29%,while control group was 70.37%.Within groups,the difference was a statistically significant in the clinical efficacy between the control group after treatment and 3 months of treatment(P<0.05),while the difference was no statistically significant between the observation group(P>0.05).Comparison between groups showed that the clinical efficacy of the two groups was compared after treatment and 3 months of treatment,and the differences were statistically significant(P<0.05).4.Safety evaluation: During the study period,the vital signs of the two groups were not abnormal.All the 3 cases of adverse reactions(1 case with mild nausea and 2 cases with mild oral discomfort)were considered to be related to budesonide formoterol powder inhaler,and no adverse reactions or accidents were found to be related to Modified Painless Purulent Moxibustion With Wheat Grain.It indicates that Modified Painless Purulent Moxibustion With Wheat Grain has great safety.Conclusion: Both groups of treatment can improve cough symptoms and TCM syndromes of CVA patients(wind-cold evil hides in lung),reduce the subjective degree of cough symptoms,and increase the FEV1 and PEF values of lung function,with definite clinical efficacy.Compared with inhalant treatment alone,Modified Painless Purulent Moxibustion With Wheat Grain combined with budesonide formoterol has more obvious advantages in improving patients’ cough symptoms,TCM syndromic manifestations,reducing subjective cough symptoms,improving lung function and short-term and long-term clinical efficacy,with better safety.It has better clinical application and promotion value.