| Objective:To observe the clinical efficacy of Shenshuaitiaozhong Decoction in the treatment of chronic renal failure syndrome of spleen deficiency and dampness and turbidity,and to explore the efficacy and safety of traditional Chinese medicine in the treatment of chronic renal disease,so as to provide a new idea for the treatment of chronic renal failure patients with spleen deficiency and dampness and turbidity and improve the quality of life.At the same time,the response degree of the diagnostic scale for chronic renal failure syndrome of spleen deficiency and dampness and turbidity was evaluated to provide better help for quantitative diagnosis of chronic renal failure clinical syndrome and judgment of curative effect.Methods:60 patients with spleen deficiency and dampness and turbidity syndrome in stage 3-5 chronic kidney disease without dialysis were selected and randomly divided into treatment group and control group.In conventional western medicine treatment based on the experimental application of renal failure in tonga,control group used the urine poisonous clear grain,one month,observe and record the two groups before treatment and after treatment,uric acid,creatinine and urea,indexes such as hemoglobin,albumin,and chronic renal failure dampness syndrome diagnosis scale pixu(spleen deficient)syndromes quantitative score,SF-short form 36 health survey scale.Results:(1)Clinical comprehensive efficacy: the total effective rate of the control group and the experimental group was 56.67% and 83.33%,respectively.The comprehensive curative effect of experimental group was better than that of control group(P<0.05).(2)SCR,BUN,UA: SCR and BUN in 2 groups were decreased before and after treatment(P<0.05),UA in the test group was decreased(P<0.05),and there was no significant difference in UA in the control group(P>0.05);After treatment,the levels of Scr,BUN and UA in experimental group were higher than those in control group(P<0.05).Hb and ALb: Comparison between the two groups before and after treatment showed that Hb and ALb in the experimental group were increased(P<0.05),while there was no statistical difference in Hb and ALb in the control group(P>0.05).After treatment,the levels of Hb and ALb in the experimental group were increased higher than those in the control group(P<0.05).Electrolyte and trace elements: Compared with before and after treatment in 2 groups,calcium increased and phosphorus decreased(P<0.05),potassium decreased in experimental group(P<0.05),but there was no significant difference in potassium in control group(P>0.05).After treatment,the effect of increasing serum calcium,decreasing serum phosphorus and potassium in experimental group was better than that in control group(P<0.05).24UPQ: Comparison between the two groups before and after treatment showed that 24-hour urinary protein decreased in the experimental group(P<0.05),while there was no statistical difference in the control group(P>0.05).The effect of 24-hour urinary protein reduction in the experimental group was better between the groups(P<0.05).(3)In terms of the efficacy of TCM syndromes,the improvement of nausea,abdominal distension and fatigue in the experimental group was significantly better than that in the control group,with statistical difference(P<0.05).In terms of the improvement of body drowsiness and weight,eating less and staying less,the two groups had similar effects(P>0.05).The effective rate of TCM syndromes in the experimental group was 86.67%,and that in the control group was 46.67%.The effective rate of TCM syndromes in the experimental group was significantly better than that in the control group,the difference was significant(P<0.01).(4)In the evaluation of reaction degree,the P values of spleen deficiency dimension,humidity and turbidity dimension and total table dimension in the test group were all less than0.01 before and after treatment,and the difference was significant before and after treatment;Greasy tongue,yellow complexion,fat tongue with tooth marks,pale tongue,pulse osmosis items P value is less than 0.01,there is a significant difference before and after treatment;The P value of bradypulse item was greater than 0.05,and there was no significant difference before and after treatment.The effect scale before and after treatment was 2.956,which was a large effect.(5)In terms of SF-36 health survey summary score,the improvement in experimental group was significantly better than that in control group,and the difference was significant(P<0.05).(6)Safety evaluation: Compared with before treatment,there were no obvious abnormalities in stool routine,ECG and liver function in the two groups.Conclusions: renal failure decoction on chronic renal failure in the wet muddy syndrome pixu(spleen deficient)has better clinical curative effect,compared with the control group,can obviously improve the patient’s symptoms and syndromes quantitative score,can effectively improve patient quality of life,and no obvious adverse reaction occurred,clinical treatment of chronic renal failure can be used as wet muddy pixu(spleen deficient)certificate of a good choice.The effect scale of the diagnostic scale for syndrome of spleen deficiency and dampness and turbidity in chronic renal failure is large effect,and the response degree is good,which indicates that the scale can provide better help for quantitative diagnosis of clinical syndrome and judgment of curative effect of syndrome of spleen deficiency and dampness and turbidity in chronic renal failure. |
