| Objectives:A retrospective study was conducted by investigating the differences of clinical characteristic between in-patients of bullous pemphigoid(BP)with anti-BP 180 antibody positive and anti-BP 180 antibody negative in order to improve the knowledge and diagnosis of bullous pemphigoid.Methods:Medical records of patients hospitalized for BP in the Second Affiliated Hospital of Kunming Medical University from January 2002 to August 2020 were reviewed.Cases were divided into two groups:anti-BP 180 antibody positive group and anti-BP180 antibody negative group according to whether their anti-BP180 antibody was positive or not.General information,onset condition,initial symptoms,course of disease,main laboratory examinations,autoantibody examinations,imaging examinations and main therapeutic medications of patients at the first hospital stay were collected.According to the type and purpose of data,SPSS25.0 was used to compare the differences between the two groups,such as t-test,chi-square test,rank sum test and Fisher exact probability method,the indexes with differences between the two groups were analyzed by multivariate analysis.Results:1.120 patients met the inclusion criteria,including 80 males(66.67%)and 40 females(33.33%,The sex ratio(female:male)was 1:2.A total of 87 BP patients(72.5%)were anti-BP 180 antibody positive,including 56 males(64.4%)and 31 females(35.6%),the sex ratio(female:male)was 1:1.7.There were 33 BP patients with negative anti-BP180 antibody(27.5%),including 24 males(72.7%)and 9 females(27.3%),the sex ratio(female:male)was 1:2.6.There was no significant difference in gender composition between the two groups.The average age of anti-BP180 antibody positive group was 72.4 years(95%CI 69.6-79.2 years),the median age was 74 years(range 25-96 years).The average age of anti-BP180 antibody negative group was 62.73 years(95%CI 55.4-69.9 years),and the median age was 65 years(range 1-90 years).The age of anti-BP180 positive group was significantly older than that of anti-BP180 negative group(P=0.016).The number of facial lesions in the anti-BP180 antibody negative group was more than that in the positive group(36.4%vs 17.2%,P=0.025).The lower limbs were more involved in the anti-BP180 antibody positive group than in the negative group(96.6%vs 81.8%,P=0.019).2.The number of grade I nursing in the anti-BP180 antibody positive group was higher(46%vs 21.2%,P=0.013).In terms of the number of critical cases,the number of bedridden patients,the days of hospitalization and the utilization rate of immunosuppressants,the anti-BP180 antibody positive group was higher,but the difference was not statistically significant.3.The number of anti-BP180 antibody positive groups with pulmonary infection(29.9%vs 121%,P=0.045),cerebrovascular disease(26.4%vs 9.1%,P=0.039),hypertension(40.2%vs 18.2%,P=0.023)was higher than that in the negative group.4.Serum albumin(30.89±6.4g/L vs 33.49±5.37g/L,P=0.041),total cholesterol(3.82 mmol/L vs 4.37 mmol/L,P=0.038)in the anti-BP 180 antibody positive group were lower than those in the negative group,while D-dimer(2.69 ug/ml vs 0.83 ug/ml,P<0.001)and fibrinogen degradation products(8.57 ug/ml vs 3.66 ug/ml,P<0.001)in the anti-BP 180 antibody positive group were higher than those in the negative group.The results of multivariate analysis showed that D-dimer was related to the positive anti-BP 180 antibody.Conclusion:BP is more common in elderly men,and the positive rate of anti-BP 180 antibody was 72.5%.This D-dimer is related to the positive anti-BP 180 antibody,and they were more likely to be complicated with pulmonary infection,cerebrovascular disease and hypertension. |
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