A Preliminary Study On Changes Of Urine Makers In Patients With And Without Prostate Cancer

Objective: By comparing the difference between the routine urine indicators of prostate cancer patients and non-prostate cancer patients,we preliminarily explored whether the routine urine indicators of domestic patients are helpful in the early diagnosis of prostate cancer.Methods: 600 clinical cases of prostate cancer,prostate hyperplasia and healthy patients admitted to our hospital from 2018 to 2020,who met the inclusion criteria,were retrospectively analyzed.The clinical data of200 cases of prostate cancer,200 cases of prostate hyperplasia and 200 cases of healthy people were analyzed retrospectively.The data including age,urine pH value,urine specific gravity,urine choleogen,urine white blood cell,urine red blood cell,Gleason score,TPSA value,CPSA value,prostate size and pathological classification were statistically analyzed.Results:Among the three groups,there were statistically significant differences in urine pH value,urine white blood cell and urine red blood cell(P <0.05),but no statistically significant differences in urine cholagenia and urine specific gravity(P >0.05).2.There were statistically significant differences in urine pH value and urine white blood cells between group A and group C(P <0.05),but no statistically significant differences in urine gallbladder,urine specific gravity and urine red blood cells(P >0.05).3.There was statistically significant difference in urine erythrocytes between group B and group C(P <0.05),but there was no statistically significant difference in urine pH,urine cholagenia,urine specific gravity and urine white blood cells(P >0.05).In group A: 1.There was no statistical significance in age,urine pH value,urine specific gravity,urine gallbladder,urine red blood cell and urine white blood cell among the samples with different Gleason scores(P >0.05).2.There were statistically significant differences in age and urine white blood cells among different staging samples(P <0.05),while there were no statistically significant differences in urine pH value,urine red blood cell,urine specific gravity and urine cholagenia among different staging samples(P >0.05).ROC curves were constructed for urine pH value,urine white blood cell and age to judge their value for staging.The AUC value corresponding to urine white blood cell and age was less than 0.5,which indicated low prediction accuracy and was not suitable for prediction.The AUC value corresponding to the urine pH value was0.542,and the AUC value was all lower than 0.7,indicating that the value of urine pH value for the diagnosis of staging was relatively low.3.There was statistically significant difference in age(P <0.05)among the samples of different volume groups,while there was no statistically significant difference in urine pH,urine specific gravity,urine cholagenia,urine white blood cells and urine red blood cells(P >0.05).Conclusions: 1.The urine pH value of prostate cancer patients was significantly lower than that of BPH patients and healthy subjects,and there were significant differences in urine white blood cells,and there were significant differences in urine red blood cells between BPH group and prostate cancer group and healthy subjects.2.There was no significant correlation between age,urine pH value,urine specific gravity,urine gallbladder,urine red blood cell,urine white blood cell and tumor aggressiveness.3.Urine white blood cell and age are correlated with different clinical stages of prostate cancer,but the prediction accuracy is low and not suitable for prediction,while urine pH value,urine specific gravity,urine gallbladder,urine red blood cell and tumor stage have no significant correlation.4.Age was positively correlated with prostate volume,while urine pH,urine specific gravity,urine biliary,urine white blood cells,urine red blood cells had no significant correlation with prostate volume.