The Correlation Research Between 24-hour Urine Sodium And Blood Pressure Variability And Target Organ Damage

Objective:To examine the relationship between urinary sodium level and blood pressure variability in patients with hypertension,and to further identify the damage from blood pressure variability to target organs.Methods:1.Selected 233 patients with essential hypertension who were treated in the Department of Cardiovascular Medicine,Chengdu Fifth People’s Hospital from April 2019 to September 2019,aged 24 to 91,with an average age of 62.97±13.82,of which 122 were males Cases,111 cases were women.The patient’s informed consent was obtained for sample collection.2.Accumulate the patient’s height,weight,biochemistry,24-hour urine specimens,and other basic indicators,complete the non-invasive ambulatory blood pressure monitoring,and enhance the ultrasound investigation of the heart and carotid artery.3.The urine sodium level in this study is 154±72mmol,according to the WHO management,the daily salt intake is<6g,which is converted into urine sodium,which is 100mmol.The elected patients were separated into three groups,low(<100mol)sodium,medium(100mol to 200mmol)sodium,and high(>200mol)sodium groups.4.Practice the SPSS 25 software to scrutinize the data,and the common frequency measurement data are expressed as mean±standard deviation.One-way examination of variance was used to compare the means among multiple groups.A Chi-square examination was used to distinguish count data between groups.Correlation analysis adopts Pearson correlation analysis.Multiple stepwise regression analysis of target organ factors related to blood pressure variability.P<0.05 intimates that the variation is statistically meaningful.Results:1.The body weight,BMI,TC,and LDL-C of the high urine sodium group were higher than those of the medium and low sodium groups.2.The 24h SBP,24h DBP,d SBP,d DBP,n SBP,and n DBP of the high urine sodium group were higher than those of the middle and low urine sodium groups.In the comparison of blood pressure variability,the 24h SSD and d SSD of the high sodium urine group were higher than those of the medium urine sodium and low urine sodium group,and the 24h DCV were lower than the medium urine sodium group,and d DCV were lower than the low urine sodium group.3.Urine sodium level was positively associated with 24h SBP,24h DBP,24h SSD,24h DSD,d SBP,d SSD,n SSD,n SBP,n DBP.Then negatively associated with 24h DCV and d DCV.In the correlation analysis with target organs,urine sodium was correlated with IMT and 24-hour urine protein quantification(P>0.05).4.The consequence of urine sodium on 24h SSD,24h DCV,d SSD,d DCV,n SSD is statistically significant,and the effect of age and HDL on 24h DCV and d DCV is statistically meaningful.5.The 24h SBP,24h DBP,d SBP,d DBP,n SBP,d DSD,n DCV and urine sodium of the urine protein positive group were higher than those of the common group.6.The 24h SBP,d SBP,n SBP,d DBP,and urine sodium of the carotid artery intimal thickening group was higher than those of the normal intimal group.Conclusions:Inside those hypertensive patients,those with excessive salt consumption have higher BMI,TC,and LDL-C.24-hour and daytime systolic blood pressure variability was increased in patients with excessive salt intake.Besides,salt intake and average blood pressure level.Also,the increase in blood pressure variability is related to the increase in urine microalbumin.