The Clinical Research Of Tiaogan Lipi Formula In The Treatment Of Chronic Hepatitis B With Hepatic Fibrosis(Liver Stagnation And Spleen Deficiency Type)

Objective: To observe the clinical efficacy of Tiaogan Lipi Formula in the treatment of Chronic Hepatitis B with Hepatic Fibrosis(Liver Stagnation and Spleen Deficiency Type),to provide efficacy and safety Evidence-based medical evidence for the treatment of Hepatitis B Liver Fibrosis,and to provide reliable clinical guidance and reference project.Methods: 68 patients who met the inclusion criteria were randomly divided into the treatment group and the control group,34 cases each.The treatment group was treated with Tiaogan Lipi Formula,while the control group was treated with Biejiajian Pill.Two groups of the course of treatment is 12 weeks.After the course of treatment,the comprehensive curative effect,TCM syndromes curative effect,liver function comparison,the value of Transient Elastography detection,APRI scores before and after treatment were statistically analyzed,then the medicine safety was evaluated.Results:1.The comprehensive curative effect: After treatment,the total effective rate of the treatment group was 86.66%,and it was 61.29% in control patients,P<0.05,the difference was statistically significant.2.TCM symptoms curative effect: After treatment,the symptoms integral effect of the total effective rate was 90.00% in treatment group,it was 64.51% in control group,P<0.05,the difference was statistically significant.3.Liver function: Before the treatment,The treatment group in ALT/AST,compared with control group,P>0.05,there was no statistically significant difference,after treatment,the treatment group in ALT/AST,compared with the control group,P<0.05,the difference was statistically significant.4.The value of Transient Elastography detection: Before the treatment,the treatment group in the value of Transient Elastography detection compared with control group,P>0.05,there was no statistically significant difference,after treatment,the treatment group in the value of Transient Elastography detection,compared with the control group,P<0.05,the difference was statistically significant.5.APRI scores: Both medicine could significantly reduce APRI scores in patients.Before the treatment,the treatment group in APRI scores compared with control group,P>0.05,there was no statistically significant difference,after treatment,the treatment group in APRI scores,compared with the control group,P<0.05,the difference was statistically significant.6.Safety:During the treatment period,no obvious adverse reactions occurred in the treatment group,and the medication is safety.Conclusion:1.Tiaogan Lipi Formula can effectively improve the clinical symptoms of Chronic Hepatitis B with Hepatic Fibrosis(Liver Stagnation and Spleen Deficiency Type)and improve their quality of life.2.Tiaogan Lipi Formula has the effect of improving the comprehensive curative effect,TCM syndromes curative effect,can effectively improve liver function indexes,the value of Transient Elastography detection and APRI scores.3.During the treatment of Tiaogan Lipi Formula,no obvious adverse reactions occurred,and the medication was safe and effective,it is worthy of being applied in clinical practice.