Effect Of Zhuituxiao Capsule On Lumbar Disc Herniation Of Blood Stasis And Dampness Type And Its Effect On Serum NF-κB Signal Pathway

Objective:To observe the clinical efficacy of Zhuituxiao Capsules on lumbar disc herniation of blood stasis and dampness type and its effect on the serum NF-κB signaling pathway,and to provide preliminary research for exploring the mechanism of the clinical efficacy of Zhuituxiao Capsules.Methods:Taking 60 patients with lumbar disc herniation of blood stasis and dampness type as the research object,and dividing them into test group and control group randomly.All were given basic treatment(bed rest,lumbar traction,functional exercise),on the basis of basic treatment,the test group was orally administered Zhuituxiao capsules and the control group was orally administered celecoxib capsules for 2 weeks.Before and after treatment,VAS score,JOA score,TCM syndrome score,serum p65 content,serum TNF-α content,serum IL-6 content and the occurrence of adverse reactions were used as observation indicators.And conduct a comparative analysis of data within and between groups.All data are analyzed by spss.20 software,P<0.05 was considered to be statistically significant.Results:(1)Before treatment,the age,gender,course of disease,TCM syndrome score,VAS score,JOA score,serum p65 content,serum TNF-α content,and serum IL-6 content of the test group and the control group were statistically analyzed,and the differences were not statistically significant(P>0.05).(2)After treatment,the test group and the control group all improved in TCM syndrome score,serum IL-6 content,serum TNF-α content,and serum p65 content,and the difference was statistically significant(P<0.05).Comparing the TCM syndrome score,serum p65 content,TNF-α content,and serum IL-6 content between the two groups,the difference was statistically significant(P<0.05).(3)After treatment,the VAS score and JOA score of the test group and the control group all improved,and the difference was statistically significant(P<0.05).Comparing the two groups’ VAS score and JOA score,the difference was not statistically significant(P>0.05).(4)Comparing the efficacy of TCM syndromes between the two groups after intervention treatment,the effective rate of the experimental group was 96.67%,and the effective rate of the control group was 66.67%.The difference was statistically significant(P<0.05).(5)During the two-week treatment period,1patient in the test group had mild diarrhea after taking the medicine,accounting for 3.33%(1/30);2 patients in the control group had abdominal pain,accounting for 6.25%(2/32).The adverse reactions between the two groups were statistically analyzed,and the difference was not statistically significant(P>0.05).Conclusion:Zhuituxiao Capsule can significantly improve the clinical symptoms of lumbar disc herniation with blood stasis and dampness type,and its mechanism of action may be related to the activation of the serum NF-κB signaling pathway.