Study On The Correlation Of TNM Staging Of Colorectal Cancer With Constitution And Syndrome Types Of Traditional Chinese Medicine

Objective: To provide reference basis for the prevention and treatment of Colorectal Cancer by analyzing the relationship between TNM staging of colorectal cancer,Chinese medicine constitution and Chinese medicine syndrome type.Methods: Patients who were clinically judged as having colorectal cancer after visiting the Department of General Surgery in the Second People’s Hospital of Fujian Province from January 20020 to January 2021 were included in the questionnaire before operation.The related scales in the questionnaire included general symptoms,TCM syndrome differentiation and TCM constitution determination.The pathological data of patients were collected after operation.Using SPSS 26.0 software and EXCEL spreadsheet,the relationships among TNM staging,TCM syndrome type and constitution of colorectal cancer were explored through statistical analysis based on the inclusion and exclusion criteria.Result: 1.A total of 131 eligible cases were collected,with an average onset age of67.39±11.96 years old and a male to female ratio of 1.91:1.The mean age of the sample was67.39±11.96 years.The main age group was(60-74)years old,in which the pre-geriatric group accounted for 49.62%,and the elderly group accounted for 26.72%.2.The population distribution of this case is most common in the elderly,with more men than women.3.The distribution of pathological TNM staging: the distribution of TNM staging composition ratio of patients with colorectal cancer is different,and the difference is statistically significant.The most common is TNM Ⅲ stage.The proportion of stage 0patients is 3.1%,the proportions of stage I,stage II,and stage III are 18.3%,29.0%,and43.5%,respectively.Stage 0 mainly occurs in the middle and early old age,Stage I in the early old age,and Stage II in the early old age,the elderly and the long-lived elderly.4.Distribution of TCM syndrome types: the difference in distribution of syndrome types is statistically significant(P<0.01).In patients with colorectal cancer,spleen deficiency and qi stagnation,dampness-heat accumulation and deficiency of liver and kidney are common syndromes,and there are many syndromes of deficiency and excess.Among them,spleen deficiency and qi stagnation accounts for 34.35%,damp-heat accumulation accounts for34.35%,and liver-kidney deficiency accounts for 13.74%.5.There were differences in TCM syndrome types among different TNM stages(P<0.05);Stage I was mainly characterized by spleen deficiency and qi stagnation,stage Ⅱ was characterized by damp-heat accumulation,and stage Ⅲ was characterized by spleen deficiency and qi stagnation.In other words,the mixed syndromes of deficiency and excess were the main symptoms in different pathological stages of colorectal cancer.6.TCM constitution distribution:(P<0.01).According to the statistical results,the most common constitutions in the patients with colorectal cancer are: dampness-heat constitution,qi-deficiency constitution,yin-deficiency constitution,blood stasis constitution,qi-stagnation constitution,phlegm-dampness constitution and yang-deficiency constitution.In this study,the majority of patients have a combination of different constitutions.As the disease progresses,the combined constitutions of non-qi-deficiency,non-yang-deficiency,non-blood-stasis and non-phlegm-dampness have stronger negative correlation with the human body.The non-qi-deficient constitution was the main negative correlation factor,and the qi-deficient constitution has the greatest influence on the overall correlation.However,due to the limited sample size and the complexity of intermingled constitutions,no meaningful results could be obtained.7.Dampness-heat constitution receives the most attention in this study,followed by qi-deficiency constitution.Stage I is mainly due to qi-deficiency,stage Ⅱ is mainly due to dampness-heat,stage Ⅲ is mainly due to qi-deficiency,and stage Ⅳ is mainly due to phlegm-dampness and dampness-heat.8.The syndrome of spleen deficiency and qi-stagnation is related to the constitution of traditional Chinese medicine.Qi-deficiency,phlegm-dampness,dampness-heat,qi-stagnation,and yang-deficiency all affect the generation of spleen-deficiency and qi-stagnation syndromes.9.The internal accumulation of dampness-heat is related to TCM constitutions,and yin-deficiency of is a risk factor for the internal accumulation of dampness-heat.Conclusion:1.In this study,patients with colorectal cancer are more common in the elderly,and the age group with a high incidence is 69 years old.with more men than women.2.The TNM staging of colorectal cancer concentrates on stage Ⅱ and stage Ⅲ,especially stage Ⅲ.3.In patients with colorectal cancer,spleen deficiency and qi-stagnation,dampness-heat accumulation,liver and kidney deficiency are common syndromes,and there are many syndromes of deficiency and excess.4.There is a correlation between TCM syndrome types and TNM staging: stage Ⅰ is dominated by spleen deficiency and qi-stagnation syndrome,stage Ⅱ is dominated by dampness-heat internal accumulation syndrome,and stage Ⅲ is dominated by spleen deficiency and qi-stagnation syndrome.5.TNM staging of colorectal cancer is related to constitutions: stage I is mainly due to qi-deficiency,stage Ⅱ is mainly due to dampness-heat,stage Ⅲ is mainly due to qi-deficiency,and stage Ⅳ is mainly due to phlegm-dampness and dampness-heat.6.TCM syndromes of colorectal cancer are related to constitutions: spleen deficiency and qi-stagnation syndrome is related to TCM constitutions.Qi-deficiency,phlegm-dampness,dampness-heat,qi-stagnation,and yang-deficiency all affect the generation of spleen deficiency and qi-stagnation syndrome.Dampness-heat accumulation syndrome is related to TCM constitutions,and yin-deficiency is closely related to the internal accumulation of dampness-heat.