Clinical Observation On The Efficacy Of Using The Method Of Conditioning Chongren Disharmony In The Treatment Of Female Late-Onset Acne

Objective:To observe the clinical effect of conditioning Chongren disharmony in the treatment of female late-onset acne Methods:Randomized controlled trial method was adopted in this study to select patients who visited the Dermatology Clinic of the First Affiliated Hospital,Heilongjiang University of Chinese Medicine from August 2020 to February2021 and met the selection criteria.The qualified patients were randomly divided into treatment group and control group,32 patients for each group,respectively.The patients in the treatment group and in the control group were asked to take traditional Chinese medicine decotion and Tanshinone Capsule orally,respectively.Two weeks as a course of the treatment,patients were asked to have subsequent visit every two weeks,their conditions were recorded for three courses of the treatment,including their skin lesion and TCM syndrome grades before treatment,two weeks after treatment,four weeks after treatment and six weeks after treatment.then calculated and compared the clinical effects of the two groups.In addition,their sex hormone test were taken to observe the changes before and after treatment.Both the inter-group and intra-group difference were analyzed with SPSS software.Results:1.After 2 weeks of treatment,the skin lesions and TCM syndrome scores of the two groups of patients were compared between and within groups(P>0.05),which was not statistically significant.After 4 weeks of treatment,the skin lesions and TCM syndrome scores of the two groups of patients were improved compared with those before and after 2 weeks of treatment,and the improvement of the treatment group was better than that of the control group(P<0.05).After 6 weeks of treatment,the skin lesions and TCM syndrome scores of the two groups of patients were significantly improved compared with those before treatment,2 weeks of treatment,and 4weeks of treatment,and the improvement of the treatment group was significantly better than that of the control group(P<0.05).2.In the treatment group,2 cases were cured,14 cases were markedly effective,11 cases were effective,5 cases were ineffective,and the effective rate was 84.36%.In the control group,0 cases were cured,6 cases were markedly effective,15 cases were effective,and 11 cases were ineffective.The effective rate was 65.63%.Comparison between the treatment group and the control group,P<0.05,which is statistically significant.3.After 6 weeks of treatment,compared with the sex hormone levels of the two groups,T decreased and E2 increased,which was statistically significant.The levels of LH,PRL,PROG and FSH before and after treatment in the three groups did not change significantly(P>0.05).4.The liver function,renal function,and ECG of the two groups of patients were tested before treatment and 6 weeks after treatment,and the indicators were all within the normal range.The two groups of patients had no adverse reactions during the treatment period.Conclusions:1.The method of conditioning Chongren disharmony in the treatment of female late-onset acne can effectively improve symptoms,and the efficacy is better than tanshinone capsule.2.The method of conditioning Chongren disharmony is a safe and effective method for the clinical treatment of female late-onset acne.