Analysis Of Factors Related To Failure Of Eradication Of Helicobacter Pylori

Objective: To study the effects of gender,age,body mass index,occupation,education level,Home address,smoking,drinking,gastrointestinal tract diseases,diabetes and compliance on the eradication rate of Helicobacter pylori.Method: Selected from June 2019 to December 2020 in our hospital’s gastroenterology outpatient department through electronic gastroscopy and gastric mucosal biopsy or 13 C urea breath test confirmed H.Pylori positive,while electronic gastroscopy showed chronic gastritis or peptic ulcer(Gastric ulcer or duodenal ulcer,except those with compound ulcer)270patients,aged 18～75 years old.Record the patient’s name,gender,age,body mass index(BMI),occupation,home address,education level,smoking and drinking status,combined upper gastrointestinal tract disease,combined diabetes at the beginning of the trial through questionnaires And other information and contact information.A unified bismuth-containing quadruple eradication program(rabeprazole sodium enteric-coated capsules+ bismuth potassium citrate tablets + amoxicillin capsules + clarithromycin dispersible tablets)was given,and the treatment course was 14 days.After the course of treatment,the patient’s compliance,smoking,drinking,and adverse reactions were recorded by telephone return visits.The 13 C urea breath test was reviewed 4～6 weeks after the drug was stopped,and the patient’s review results were recorded by telephone return visits again.Groups were grouped according to the 13C-UBT test results.Those with negative re-examination results were included in the successful H.Pylori eradication group,and those with positive results were included in the eradication failure group.A single factor analysis was performed on the relevant factors of the study,and the single factors with statistical differences between the groups were compared,and then a multi-factor Logistic regression analysis was performed.Results: A total of 270 patients were included in this study.Among them,4 cases were lost to follow-up,2 cases were not rechecked for 13 C urea breath test after treatment,and 264 cases remained after excluding those with incomplete data;201 cases of Helicobacter pylori were successfully eradicated,63 cases failed to be eradicated,and the eradication rate of Helicobacter pylori was 76.14%.Univariate analysis suggests that there are statistically significant differences in smoking,diabetes,BMI and compliance between groups;Multivariate logistic regression analysis showed that smoking(OR 7.394,95%CI 1.483～36.855,P=0.015),combined diabetes(OR 2.707,95%CI 1.049～6.989,P=0.040)and BMI ≥25Kg/m2(OR 6.100,95%CI 1.257～29.611,P=0.025)is an independent risk factor for H.pylori eradication failure.Good compliance(OR 0.261,95% CI 0.106～0.641,P=0.003)is a protective factor for the successful eradication of H.pylori.Conclusion: 1.The results of this study show that the eradication rate of Helicobacter pylori is 76.14%;2.Gender,age,occupation,education level,home address,drinking and gastrointestinal diseases have no significant effect on the eradication rate of Helicobacter pylori;3.Smoking,diabetes and BMI ≥ 25Kg/m2 are independent risk factors for the failure of Helicobacter pylori eradication;good compliance is a protective factor for successful Helicobacter pylori eradication.