Analysis Of The Effect Of Olfactory Training Combined With Nasal Spray Of Nerve Growth Factor On Patients With Olfactory Disorders

Objectives: Explore the therapeutic effect of olfactory training combined with nerve growth factor on patients with olfactory disorders.Material and Methods: The experimental group selected 16 patients with olfactory dysfunction caused by head trauma or upper respiratory tract infection in our hospital’s Otorhinolaryngology Clinic from December 2019 to December2020,including 6 males and 10 females,aged 20-80 Years old,average(45.00±14.56)years old;course of disease 0.2-60 months,average(10.84±14.36)months,instruct patients to apply olfactory training combined with nasal growth factor treatment.In the control group,31 patients who had been clinically diagnosed as head trauma or olfactory disturbance caused by upper respiratory tract infection in our hospital’s Otolaryngology Clinic were selected for the control group.Among them,there were 10 males and 21 females,with an average age of 20-80 years.(48.74±16.95)years old;the course of disease was 0.2-60 months,with an average of(12.74±11.95)months.Sniffin Sticks detection scores were collected before treatment,1 month after treatment,and 3 months after treatment.The treatment effect is expressed by the difference between the olfactory score 1 and 3 months after treatment and the score before treatment.After treatment,the olfactory test score increases by more than 6 points as the treatment is effective.The Fisher exact probability method of four grid table data was used to compare the effective rate,and the comparison of the treatment effect was compared with the independent sample t test,and the difference was statistically significant with P<0.05.Results: After one month of treatment,the effective rate of treatment in the experimental group was 68.8%(11/16)and that in the control group was 16.1%(5/31).The effective rate of the experimental group was significantly higher than that of the control group(P<0.01).Comparing the treatment effects,the olfactory score of the experimental group increased to 7.66±6.52 points,and the control group was 2.32±3.17 points.The difference between the olfactory score of the experimental group and the score before treatment one month after treatment was significantly higher than that of the control group(P<0.01).After three months of treatment,the effective rate of treatment in the experimental group was 68.8%(11/16),which was higher than 58.1%(18/31)in the control group,but there was no significant difference(P>0.05).Comparing the treatment effects,the olfactory score of the experimental group increased to 10.44±8.53 points,which was also higher than that of the control group,which was 6.84±7.78 points,with no significant difference(P>0.05).Conclusion: Both treatment methods have good therapeutic effects on upper respiratory tract infection and traumatic olfactory disorders.The early effect of olfactory training combined with NGF in the treatment of upper respiratory tract infection and traumatic olfactory disorders is significantly better than that of olfactory training alone,suggesting that olfactory training combined with NGF can improve the patient’s sense of smell more quickly.