The Study Of The Relationship Between The Intak Of Mushroom And Algae Food Before And Gestational Diabetes Mellitus In Northeast China

Objective:This study was conducted to explore the association between intake frequency of mushrooms and algae food during progestation and gestational diabetes mellitus.Methods:The study population came from the maternal-child-adolescent cohort of the National Key R&D Program of China-“China Northeast Cohort Study”.The data of pregnant women were collected by Shengjing Hospital maternity clinic of China Medical University for OGTT test from December 2018 to December 2020.A total of 2152 subjects were included.According to the intake frequency of mushrooms and algae food,pregnant women were divided into"hardly eat","<2-3 times a week","≥2-3 times a week",Chi-squared Test were used to deal with the difference of continuity and classification variables.Meanwhile,t-test and chi square test were used to deal with the characteristics of GDM group and non GDM group.We used multivariate logistic regression to estimate the value of odds ratio(OR)and 95%confidence interval(95%CI)with GDM as the dependent variable and intake frequency of mushrooms and algae food as the independent variable.Ultimately,we used age factors(≥35 years old and<35 years old)and Pregnancy BMI(BMI<18.5kg/m~2,18.5kg/m~2≤BMI<24kg/m~2,BMI≥24kg/m~2)as subgroups for subgroup analysis.The analysis methods of subgroups were same with with the above.Results:The study found that the prevalence of GDM was 21.28%in this population.Through the analysis of t-test and chi square test,we found that there were statistical differences in age,whether the first pregnancy,Height during pregnancy,Pregnancy weight and BMI during pregnancy.The results showed that there was no correlation betweenintake frequency of mushrooms and algae food and GDM.More research and larger sample size are needed to verify the association between mushrooms and algae food and GDM.The intake level of prepregnancy bacteria and algae food in GDM group was higher than that in non-GDM group(8.09±0.34 VS7.57±0.18,P=0.172;).the total intake level of mushrooms/Flammulina velutipes and other fungi before pregnancy in the non-GDM group was higher than that in the GDM group(4.55±0.12 VS 5.08±0.23,P=0.042*;)And had statistical significance.Among them,in both GDM group and non-GDM group,the intake levels of mushrooms/Flammulina velutipes and other fungi before pregnancy were significantly higher than those of the other two types of bacteria and algae,auricularia auriculata and seagrass before pregnancy(GDM:4.55±0.12 VS 1.29±0.07 VS 1.72±0.12;Non-GDM:5.08±0.23 VS 1.24±0.04 VS 1.77±0.06;)Covariate factors,such as age,pre-pregnancy BMI,occupation,first pregnancy,family history of gestational diabetes mellitus,family history of gestational hypertension,oral contraceptives,and total energy intake,were adjusted according to the characteristics of the study.The results of Logistic model showed that there was no correlation between food intake of various types of bacteria and algae before pregnancy and GDM.At the same time,the results of subgroup analysis showed that,after adjusting for covariate factors,the results of 18.5<Pregnancy BMI<24 percent of pregnant women;The frequency of intake of seagrass before pregnancy<2-3 times/week was a protective factor of GDM,and it was statistically significant.(<2-3 times/week:OR(95%)=0.64(0.45,0.89),P<0.05~*).In addition,the correlation between prepregnancy BMI>24and prepregnancy BMI was significantly higher than that of prepregnancy BMI>24.Seagrass intake frequency of<2-3 times per week before pregnancy was a risk factor for GDM,and it was statistically significant.(<2-3 times/week:OR(95%)=1.43(1.06,1.96),P<0.05~*).Conclusion:There was no statistical correlation between prepregnancy algal intake frequency and GDM.Due to the lack of relevant studies,more studies and larger sample sizes are needed in the future to test and verify the correlation between the two.However,the present study found that at 18.5<Pregnancy BMI<24 pregnant women,there was a correlation between mushroom/Flammulina intake frequency and GDM in the second trimester,showing a protective effect.In pregnant women with pre-pregnancy BMI>24,the frequency of prepregnancy seagrass intake was associated with GDM and showed a harmful effect.