| Objectives Retrospective analysis of recombinant human growth hormone(rh GH)treatment of children with different diseases for 3 and 6 months,their height(Ht),height standard deviation score(Ht SDS),growth velocity(GV)and other indicators to analyze the clinical efficacy of rh GH.Methods A collection of 140 children who received recombinant human growth hormone therapy in the department of pediatrics of Hebei Province People’s Hospital from July 2017 to June 2020,including 75 children with growth hormone deficiency(GHD)(41males,34 females),43 children with idiopathic short stature(ISS)(31 males,12 females),4children with turner syndrome(TS)(0 males,4 females),7 children with central precocious puberty(CPP)(1 male and 6 female),and 11 children wanna height-promoting(9 males and 2 females).The initial therapeutic dose for children with GHD is 0.10-0.15IU/kg/d,and the initial therapeutic dose for children with ISS is 0.12-0.15IU/kg/d.The initial treatment dose for children with TS,CPP and height promotion is 0.15-0.17IU/kg/d,and the maximum dose generally does not exceed 0.20IU/kg/d.It is injected subcutaneously every night before going to bed.The injection site can be around the umbilicus,upper arm,and outer thigh,and can be changed each time.During the period,the dosage of the drug was adjusted appropriately according to the curative effect,IGF-1 and weight change.In addition,children with CPP were treated with leuprolide acetate at a dose of 30ug/(kg.times),the maximum dose was 3.75mg/time,and a course of treatment every 4 weeks.After every 3 months of treatment,IGF-I,glycosylated hemoglobin,thyroid function,height and weight were measured in the pediatric clinic of our hospital.Results 1 A total of 140 children were included in this study,including 82 males and 58 females,with an average age of 7.86±3.15 years old,most of which were children over 8years old.Among 140 cases of children(129 cases of short stature),GHD is the most,accounting for about 53.6%,followed by ISS,accounting for about 30.7%.2 After 3months and 6 months of treatment in children with GHD,Ht,Ht SDS,Wt,GV,and IGF-1were all higher than before,and there were significant differences before and after treatment(all P<0.05).3 After 3 months and 6 months of treatment in children with ISS,Ht,Ht SDS,Wt,GV,and IGF-1 were all higher than before,and there were significant differences before and after treatment(all P<0.05).4 Ht,Ht SDS,Wt,and BMI of children with GHD before and after treatment were higher than those of children with ISS;IGF-1 of children with GHD before treatment was lower than that of children with ISS,but after treatment it was higher than that of children with ISS;the above two groups The difference was not statistically significant(all P>0.05);GV of children with GHD was higher than that of children with ISS before and after treatment,and the difference between the two groups was statistically significant(all P<0.05).5 After 3 and 6 months of treatment in children with TS,Ht,Ht SDS,Wt,GV,and IGF-1 all increased compared to before,and there were significant differences between Ht and GV before and after treatment(both P<0.05).6 After 3 months and 6 months of CPP treatment,Ht,Ht SDS,Wt,GV,and IGF-1were all higher than before,and there was no significant difference between before and after treatment(all P>0.05).7 After 3 months and 6 months of treatment for heightpromoting children,Ht,Ht SDS,Wt,GV,and IGF-1 were all higher than before,and there were significant differences between Ht,Wt,and BMI before and after treatment(All P<0.05).Conclusions 1 There are many causes of short stature,including GHD,ISS,TS,CPP,SGA,chronic systemic diseases,congenital hypothyroidism,bone and cartilage development disorders,nutritional disorders,chromosomal diseases,genes Defects,etc.2As the main medicine for treating short stature caused by GHD,ISS,CPP,TS,SGA,etc.,rh GH can effectively improve adult height.3 The curative effect of rh GH is affected by many factors,so it is necessary to choose the indication carefully and adopt individualized treatment plan.4 The safety of rh GH is generally good.The benefits and risks should be fully evaluated,and follow-up should be closely followed during the treatment process to pay attention to side effects.Figure [1];Table [7];Reference [195]... |
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