The Guiding Significance Of The Type Of Antiplatelet Membrane Glycoprotein Antibody Expression In The Therapeutic Effect Evaluation Of Pediatric Immune Thrombocytopenia

ObjectiveThis study selected from November 2020 to February 2022 admitted in our children with immune thrombocytopenia（immune thrombocytopenia,ITP）in November 2022 as the study object,explore the platelet membrane glycoprotein antibody expression type and the correlation of treatment effect evaluation,aims to find the antiplatelet membrane glycoprotein antibody expression type of clinical individualized treatment of children with ITP.MethodsITP children treated in our hospital from November 2020 to February 2022 were selected to study the correlation between the expression type of antiplatelet membrane glycoprotein antibody and the treatment effect.In this study,only children with intravenous gammaglobulin plus glucocorticoid were included for evaluation,analysis and comparison,and a total of 73 patients were enrolled.All the enrolled children collected venous blood before treatment,and the antiplatelet membrane glycoprotein antibody was detected by flow cytometry,the platelet count and bleeding before and after treatment were analyzed,and the correlation between the expression type of antiplatelet membrane glycoprotein antibody and the treatment effect was studied.Results1.In this study,73 children with ITP were selected with a male to female ratio of 1.03:1;mean age（3.5 ± 2.32）years,mean platelet count（14.5 ± 5.89）109 / L,frequently in winter,79.5% had a history of precursor infection within 6 weeks before onset,and 74.0% were associated with bleeding events.2.There was no significant difference between the positive and negative values of the four anti-platelet membrane glycoprotein-specific antibody expression in ITP children of different age groups and gender（P> 0.05）.3.Children with ITP treated with intravenous C immunoglobulin + glucocorticoid had 52 patients in good group and 21 group.General data between the two groups,age,precursor infection history and bleeding（P> 0.05）.4.The efficacy of the four antibody expression types in children with ITP was statistically different in the same intravenous gamglobulin + glucocorticoid regimen（x~2=15.608,P=0.001）.5.Logistic model: double positive antibody（OR=0.061,P=0.017）,positive anti-GPⅡb /Ⅲa antibody（OR=0.800,P=0.825）and positive anti-GPIb /Ⅸ antibody（OR=0.148,P=0.074）were inversely associated with the efficacy of intravenous gamglobulin + glucocorticoid in patients with double negative antibody.Conclusions1.Children in the double-negative antibody group and anti-GPⅡb /Ⅲa antibody positive group are sensitive to intravenous treatment of propylene globulin +glucocorticoid.The treatment of intravenous propylene globulin + glucocorticoid should be preferred in clinical treatment.2.Children in antibody double positive group and anti-GPIb /Ⅸ antibody positive group have low sensitivity to this treatment.Second-line regimen and new drug treatment can be considered in clinical treatment.