| Objective To observe the effects of Jinkui Shenqi Pill combined with olmesartan lipid tablets before and after treatment on patients with stage ?-stage ? kidney-yang deficiency diabetic nephropathy before and after treatment,TCM clinical symptom scores,and renal tubular filtration and renal tubular reabsorption Impact,to provide clinical evidence for the treatment of diabetic kidney disease(DKD)by Chinese medicine.Methods A total of 60 hospitalized patients with diabetic nephropathy with stage?-? disease of kidney-yang deficiency were equally divided into a Chinese patent medicine control group(group A),a western medicine control group(group B),and a combination of traditional Chinese and western medicine.Group(Group C).All 3 groups were given Novoline 30R 5 minutes before meals.Based on this,group A was given Jinkui Shenqi Pills;group B was given olmesartan lipid tablets;group C was given Jinkuishen Qi Pill+Olmesartan Fat Tablets.During the observation period,the three groups were given the same modern comprehensive treatment measures for diabetes,including diabetes education,reasonable diet,appropriate exercise,control of blood pressure and blood lipids,daily self-tested 4 levels of urine glucose,etc.,4 weeks as a course of continuous observation 3 courses.Observe the improvement of TCM syndromes,blood urea nitrogen(BUN),creatinine(SCr),and creatinine clearance(CCr),24-hour urinary protein,blood ?1 microglobulin(al-microglobulin,?1-MG),?2-microglobulin(?2-MG),and Glomerular Filtration Rate(GFR)changes in blood,analyze the test data using statistical methods,To evaluate the clinical efficacy and safety of Jinkui Shenqi Pill combined with olmesartan lipid tablets in the treatment of stage ?-? diabetic nephropathy.Results 1.There were no statistical differences in the general conditions(gender,age,course of disease,combined disease,combined medication,blood routine,liver function,renal function,fasting blood glucose,blood glucose,blood biochemistry,and urine biochemistry)of the three groups before treatment.Scientific significance(P>0.05),with clinical comparability;2.Efficacy evaluation:?Total score of TCM symptoms:The total score of TCM symptoms of patients in group C was significantly better than that of the other two groups,which was significantly different(P<0.05);the total score of TCM symptoms of patients in group A was compared with B There was no significant difference(P>0.05).? TCM individual symptom score:After treatment,the three groups of patients had dry mouth,dry throat,dryness,short urine output,weak waist and knees,fatigue,limb swelling,chills,limb coldness,shortness of breath,laziness,dark complexion,tongue The symptom scores such as pulse signs improved compared with before treatment(P<0.05);patients in group C had dry mouth,pharyngeal dryness,dryness,short urine output,weak waist and knees,fatigue,limb edema,cold chills,and shortness of breath.Speech,dark complexion,tongue pulse and other symptoms scores were lower than those in group A and group B,which was statistically significant(P<0.05);group A had chills,cold mouth,dry throat,soft waist and knees,and short urine output.The symptom score was lower than that of group B,which was statistically significant(P<0.05),and the scores of symptoms such as dryness,fatigue,shortness of breath,and edema of limbs were better than group A and had statistical significance(P<0.05).There was no significant difference between group A and group B in the symptom scores of tongue pulse and dark complexion(P>0.05).? Total clinical efficacy:The total clinical effective rate of patients in group C was 90.0%,which was significantly different from the other two groups(P<0.05);the total clinical effective rate of patients in group A was 75.0%,and the total clinical effective rate of patients in group B was 70.0%.There was no significant difference between group A and B(P>0.05).?The serum creatinine,creatinine and creatinine were significantly improved in group A(P<0.05)Microglobulin and glomerular filtration rate were better than the other two groups,with statistical significance(P<0.05);After treatment,the indexes of urea nitrogen and creatinine in group A were better than those in group B,with statistical significance(P<0.05).There was no significant difference between group A and group B in creatinine clearance rate and 24-hour urine protein quantitative index(P>0.05).3.Evaluation of safety indicators:No adverse reactions occurred in the three groups of patients before and after treatment.Conclusion Jinkui Shenqi Pill Combined with olmesartan dipivoxil tablets can improve the efficacy or integral of TCM syndromes in patients with kidney yang deficiency syndrome of stage ?-? type 2 diabetic nephropathy,and can improve some renal function,glomerular filtration index and renal tubular reabsorption index.Its effect is better than that of Chinese patent medicine or western medicine alone. |
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