Clinical Observation Of Qinglong Pingchuan Decoction On Lung-kidney Qi Deficiency And External Cold And Internal Drink Syndrome In Acute Exacerbation Of Senile Chronic Obstructive Pulmonary Disease

Objective: To observe the efficacy and safety of Qinglong Pingchuan Decoction in the treatment of elderly chronic obstructive pulmonary disease in acute exacerbation period(AECOPD)lung and kidney qi deficiency,external cold and internal drinking syndrome,as well as the degree of improvement in patients' clinical symptoms and quality of life.The treatment provides the basis for new drugs.Methods: This study selected 80 patients who were admitted to the Department of Geriatrics of the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine who met the diagnostic criteria of lung and kidney qi deficiency and external cold internal drinking syndrome during the acute exacerbation of chronic obstructive pulmonary disease.Randomly divided into two treatment groups,40 cases in the observation group and 40 cases in the control group.The control group was treated with oxygen therapy,anti-inflammatory,bronchial dilation,anti-infection,and sputum dilution.The observation group was treated with Qinglong Pingchuan Decoction on the basis of the treatment of the control group,and the course of treatment was 14 days.Observe TCM symptoms,signs,blood routine,C-reactive protein(CRP),procalcitonin(PCT),lung function,blood gas analysis,CAT score,m MRC score and other indicators.Results: 1.The general conditions(gender,age,course of disease)and observation indicators(total effective rate,total score of TCM syndromes,scores of TCM symptoms and signs,blood routine,C-reactive protein(CRP),calcitonin)before treatment of the two groups of patients The original(PCT),lung function,blood gas analysis,CAT score,m MRC score)had no difference and were comparable(P>0.05).2.Comparison within the group: the observation group and the control group after treatment,the total effective rate,the total score of TCM syndromes,the score of TCM symptoms and signs,blood routine,C-reactive protein(CRP),procalcitonin(PCT),lung function,blood gas The analysis,CAT score and m MRC score were statistically significant compared with the same group before treatment(P<0.05),indicating that each value has improved in different degrees.3.Comparison between groups: Comparing between the two groups,the observation group has more advantages in the total effective rate and TCM syndrome total points treatment,(P<0.05);the observation group can better improve cough and expectoration,sputum quality,and wheezing Symptoms of promoting and aversion to cold and sweating(P<0.05),while the treatment effects of chest tightness,nocturia,posture,and pulmonary rales were similar(P>0.05).The observation group can better improve the FEV1/FVC% value of patients(P<0.05),while the efficacy of FEV1%pred treatment between the two groups has no difference(P>0.05).For CAT score,m MRC score,inflammation index(WBC,CRP,PCT),blood gas analysis(Pa CO2,Pa O2)treatment,the observation group had better effect(P<0.05),and the NEUT% group P>0.05 after treatment,NEUT % The treatment effect of the two groups is equivalent.4.After treatment,the vital signs,liver and kidney functions of the two groups of patients were within the normal range,indicating that Qinglong Pingchuan Decoction is relatively safe for the treatment of acute exacerbation of chronic obstructive pulmonary disease.Conclusion: 1.Qinglong Pingchuan Decoction can better relieve the symptoms of senile chronic obstructive pulmonary disease in acute exacerbation of lung and kidney qi deficiency,external cold and internal drinking syndrome,coughing and sputum,wheezing,shortness of breath,sweating and aversion to cold to a certain extent.Improve the quality of life of patients,improve m MRC score and CAT score.2.Qinglong Pingchuan Decoction can improve chronic obstructive pulmonary disease in acute exacerbation of lung and kidney qi deficiency,inflammatory indicators in patients with external cold and internal drinking syndrome,control infection,reduce airway inflammation,and correct hypoxia and carbon dioxide retention in patients,thereby improving lungs Ventilation function.3.Qinglong Pingchuan Decoction has good safety in the treatment of acute exacerbation of chronic obstructive pulmonary disease in the elderly,and it can be clinically promoted and applied.