A 12-week Study Of The Effects Of Different Modalities Of Exercise Intervention On Patients With Non-alcoholic Fatty Liver Disease

Research ObjectiveTo investigate the intervention effects of three exercise modalities: high-intensity interval training,maximal fat oxidation intensity training,and resistance training on NAFLD,and to observe the effects of these three exercise modalities on subjects’ body weight,waist circumference,hip circumference,body composition,whole-body fat content,muscle content,and biochemical indexes related to blood lipid and liver function,and to promote the prevention and treatment of NAFLD disease.Research MethodsThe study population was 24 patients suffering from nonalcoholic fatty liver disease.The subjects were randomly divided into 6 in the high-intensity interval training group(group H),6 in the resistance training group(group R),6 in the maximal fat oxidation intensity training group(group F),and 6 in the control group(group C).All subjects were communicated with to ensure that they fully understood and agreed to participate in this study and signed an informed consent form.12 weeks of exercise intervention was conducted in groups H,F and R.Maximal oxygen uptake was measured by running table test.80%—90% of maximal oxygen uptake at 4 min was used for the high-intensity interval training group,followed by 50%—60% of maximal oxygen uptake at 3 min;maximal fat oxidation intensity training was measured as the exercise intensity;8-12 RM was used as the exercise intensity for the resistance training group.Relevant morphological and body composition indexes were measured,and biochemical indexes related to blood glucose and lipids(TG,TC,HDL,LDL,Apo A1,Apo B,Lp(a))and liver function(TBIL,AST,ALT,GGT)were measured.Analysis of covariance was performed using spss26.0 before and after the intervention.Research ResultsThere was no statistically significant difference(p>0.05)in the comparison of baseline data before the intervention among the four groups,and the data were matched and comparable between the groups.After 12 weeks of exercise intervention,the changes in waist circumference,ALT,and AST/ALT were statistically different(p<0.01),and there was no significant difference between groups for other indexes.All three exercise groups showed improvement in fatty liver.The differences before and after the intervention within each group were compared,and the BMI levels and body weight in group H and group F were significantly decreased(p<0.01).Waist circumference decreased significantly in all three groups after the 12-week intervention compared with the pre-intervention period(p<0.05).hip circumference and waist-to-hip ratio could be effectively reduced in groups H and R(p<0.05).All three groups had significant differences in whole body fat mass and body fat percentage after exercise intervention than before intervention(p<0.05).Only group R showed significant difference in muscle mass after 12 weeks of intervention(p<0.01),and groups H and F showed significant difference in defatted body weight after 12 weeks of intervention(p<0.05).after 12 weeks of intervention,there was no significant difference in fasting blood glucose before and after intervention in all four groups of subjects,but the amount of change in fasting blood glucose before and after intervention in all three exercise groups tended to decrease.12 weeks of HIIT could effectively improve TC levels(p<0.05)and effectively lower LDL levels(p<0.05),and LDL levels in groups R and F tended to decrease after the 12-week intervention,but the intra-group differences were not statistically significant.12 weeks of maximal fat oxidation intensity training intervention could effectively increase TC levels(p<0.05),and there was a significant difference in Apo B before and after the intervention in group H(p<0.05)and in group F Apo B before and after intervention(p<0.05),with significant differences;Apo A1/Apo B ratio in group H and group R had significant differences(p<0.05),with statistically significant differences within the groups,and Apo A1/Apo B ratio before and after intervention in group F had no significant differences.Exercise intervention in all three groups was effective in increasing AST levels,ALT levels,and GGT levels(p<0.05),which were statistically significant.AST/ALT ratios in group H(p<0.05),group R(p<0.05),and group F(p<0.01)decreased significantly after 12 weeks of intervention,with statistically significant intra-group differences.Research Conclusions(1)12-week high-intensity interval training and maximal fat oxidation intensity training can effectively reduce body weight,BMI,and Apo B levels in patients with NAFLD;they can improve waist circumference,total body fat mass,body fat percentage,AST,ALT,AST/ALT,and GGT levels in patients with NAFLD,and have a positive effect on lipid metabolism in patients with fatty liver disease.(2)Different exercise interventions differed in their improvement effects:high-intensity interval training and resistance training improved hip circumference,waist-to-hip ratio,and Apo AI/Apo B ratio in patients with non-alcoholic fatty liver disease;high-intensity interval training was advantageous in reducing de-fat body weight,TC,LDL-C indexes,and increasing HDL-C in patients with alcoholic fatty liver disease,and resistance training was advantageous in improving non-resistance training was more advantageous in improving muscle mass in patients with non-alcoholic fatty liver disease.