A Study On The Law Of Syndrome And Treatment Of Essential Hypertension With Insomina Treated By Professor Dong Guiying

Objective:To analyze and summarize the syndrome differentiation and medication rules of Professor Dong Guiying in the treatment of Essential Hypertension with Insomnia by using the "Traditional Chinese Medicine Inheritance Support System(TCMISS V2.5)",so as to provide reference for clinical diagnosis and treatment of Essential Hypertension with Insomnia.Methods:The patients with Essential Hypertension and Insomnia who were treated in the outpatient department and ward of the Hypertension Department of Jinan Hospital of Traditional Chinese Medicine from October 2020 to January 2022 were collected,and 200 patients with Essential Hypertension and Insomnia who met the inclusion criteria were selected.The medical records of the patients with the disease are entered into the "TCMISS V2.5" system,and the "statistical report" and "data analysis" functions provided by the software were used for statistical analysis of the data,and the Traditional Chinese Medicine syndrome and treatment rules by Professor Dong Guiying in the treatment of Essential Hypertension and Insomnia were summarized.Results:A total of 200 patients with Essential Hypertension accompanied by and Insomnia were included in the study,among which 124 were women(accounting for 62%)and 76 were men(accounting for 38%),with the minimum age of 23 years old and the maximum age of 70 years old,with the average age of 58.12 years old.Professor Dong Guiying used 241 kinds of traditional Chinese medicines for the treatment of Essential Hypertension with Insomnia,selection frequency of the top ten are Gastrodiae Rhizoma,Spina Date Seed,Pinellia ternata,Poria,Achyrantha bidentata,Atractylodes macrocephala,Sichuan lovase rhizome,dried tangerine peel,concha ostreae,keel.The medicinal properties of traditional Chinese medicine are mainly cold and warm,and the medicinal taste is mainly sweet,bitter and spicy.The medicine mainly belong to the liver,spleen and heart meridian.By analyzing the association rules of traditional Chinese medicine prescriptions,and setting the number of support to 80(40% support)and the confidence level to 0.95,we can get 54 combinations of commonly used drugs for treating Essential Hypertension with Insomnia,including 13 core drugs.On the basis of these 54 pairs,through further analysis,12 drug combination association rules can be obtained,in which the combination with confidence ≥0.99 is " Uncis-> Rhizoma Gastrodiae ".The 47 core combinations of 3-4 herbs were obtained by entropy clustering method of complex system.Finally,through unsupervised entropy hierarchical clustering analysis,five new prescription combinations evolved:(1)Lucid asparagus＿Pinellia ternata＿Poria＿Tangerine peel＿Achyrantha bidentata＿Atractylodes macrocephala;(2)Uncaria＿Fructus aurantii＿Polygalli＿Sea-ear Shell＿Taxillus chinensis＿Common Motherwort Herb;(3)Albizia flos＿Mulberry branch＿Dragon tooth＿lily;(4)Coptis Root＿Radix puerariae＿Cinnamon＿Sichuan lovase rhizome＿Chinese Angelica;(5)Baical skullcap root＿Sea-ear Shell＿Gardenia jasminoides＿Eucommia ulmoides＿Fructus aurantii＿Coix seed＿Peach seed＿Safflower＿earthworm.Conclusion:Through "TCMISS V2.5",the dialectical and medication rules of Professor Dong in treating Essential Hypertension with Insomnia are analyzed,and it is concluded that Essential Hypertension with Insomnia is closely related to liver,spleen and heart.In the clinical treatment of this disease,Chinese medicines for invigorating deficiency,calming the liver and relieving wind,invigorating circulation and removing blood stasis and tranquilizing are used to treat this disease.The five groups of new prescriptions are respectively modified from Erchen Decoction,Tianma Gouteng Decoction,Jiaotai Pill,and Taohong Siwu Decoction,which embodies the principle of harmonizing the liver,spleen,and heart as well as balancing wind,phlegm and blood stasis.