The Application Value Of Multimodal Ultrasound To Differential Diagnosis Benign And Malignant Breast Nodules

Objective: We analyzed the Breast Imaging Reporting and Data System(BI-RADS),enhanced-flow(e-Flow)and ultrasound elastography Strain Ratio(SR)in the application value of differential diagnosis of benign and malignant breast nodules alone and in combination with all the methods based on conventional ultrasound;we also established a combined scoring method,and explored the diagnostic efficacy of the BI-RADS & e-Flow & SR method(ie Be S scoring method)which method was used to diagnosis benign and malignant breast nodules.Methods: Patients with breast nodules who were admitted to the First Affiliated Hospital of Jiamusi University in Heilongjiang Province and underwent surgical treatment from December 2020 to February 2022 were selected as the research subjects.The postoperative pathological results were the gold standard,with a total of 107 patients and 120 nodules(A total of 117 nodules were included in the classified statistical study),and multimodal ultrasound examination was performed before surgery,including BI-RADS classification,e-Flow and SR.The ultrasound diagnosis results and pathological results were compared and analyzed by the BI-RADS classification alone,and the diagnostic value of the diagnosis results was evaluated by using the chi-square test.E-Flow and SR were combined with BI-RADS classification respectively for comparative study,and calculated the diagnostic value of the combined application of the two in differentiating benign and malignant breast nodules.Finally,by assigning scores,the BI-RADS classification,e-Flow,and SR were used in combination,and the Be S scoring method which designed in this study was used as the diagnostic criteria for benign and malignant breast nodules diagnostic criteria for lesions.Drawn Receiver Operating Characteristic Curve(ROC)to analyze the diagnostic efficacy of the four ultrasound diagnostic methods,BI-RADS classification,BI-RADS classification + e-Flow combination,BI-RADS classification + SR combination and BI-RADS classification + e-Flow + SR,then calculated the cut-off value score of multimodal ultrasound with the best diagnostic efficacy after Be S score.Results: 1.Pathological results: Among the 120 breast nodules,there are 57 benign nodules,60 malignant nodules,and 3 borderline tumors.2.BI-RADS classification have a sensitivity of 71.7%(43/60)and a specificity of 82.5%(47/57)for judging benign and malignant breast nodules.Area Under Curve(AUC)= 0.771.3.The combined application of BI-RADS classification + e-Flow had a sensitivity of 76.7%(46/60),a specificity of 82.5%(47/57),and AUC = 0.796 in judging benign and malignant breast nodules.4.The combined application of BI-RADS classification + SR had a sensitivity of 86.7%(52/60),a specificity was82.5%(47/57),and AUC=0.898 for judging benign and malignant breast nodules,2.5 is the best cutoff score.The sensitivity of multimodal ultrasound in judging benign and malignant breast nodules by Be S score was 88.3%(53/60),and the specificity was 91.2%(52/57).Conclusion: Conventional ultrasound’s BI-RADS classification,e-Flow and SR all have important reference value in the differential diagnosis of benign and malignant breast nodules,and the biological characteristics reflected by the three are different.The sensitivity and diagnostic performance of BI-RADS classification + e-Flow combination,BI-RADS classification + SR combination in diagnosing breast nodules were higher than those of BIRADS classification alone.The combined application of conventional ultrasound’s BI-RADS classification,e-Flow,and SR has greatly improved the diagnostic efficiency,which is helpful to improve the detection rate of breast cancer,and is recommended for clinical promotion.