Summary Of Professor Xie Jingri’s Medication Rules And Experience In The Treatment Of Hepatic Fibrosis

Objective:By collecting and entering the first visit cases of hepatic fibrosis patients in Prof.Jingri Xie’s outpatient case system and analyzing the statistical data of the first visit valid patients,we can summarize and promote Prof.Xie’s medication pattern and clinical experience in diagnosing hepatic fibrosis,which provides a direction for the clinical diagnosis and treatment of this disease.Methods:A retrospective study method was used to collect and record patients with hepatic fibrosis who met the inclusion and exclusion criteria in Professor Jingri Xie’s outpatient case system from January 2010 to December 2020.The cases of 135 patients were standardized and entered into an Excel 2019 form.A database based on history taking,first consultation prescriptions,standardized records,pivot tables/charts and transactional data tables was established,and correlation analysis and systematic cluster analysis were performed using IBM SPSS Modeler 18.0 and IBM SPSS Statistics 25.0 to obtain the common drug pairs and drug combinations(frequency≥ 20%)of Professor Jingri Xie.As a result,we obtained the medication pattern of Prof.Xie for the treatment of hepatic fibrosis and summarized his experience on this basis.Results:1.Of the 135 eligible patients in this study,75 were male patients and 60 were female patients,with more males than females,and the patients’ ages were concentrated in the range of 51 to 60 years.2.This study involved five TCM evidence types,and three evidence types with high frequency:liver-depression and spleen-deficiency evidence,liver and gallbladder damp-heat evidence,and phlegm-stasis interconnection evidence.3.In this study,151 commonly used Traditional Chinese medicines were counted and used 2795 times,and the top 15 frequently used medicines were Atractylodes macrocephala,Bupleurum,Astragalus membranaceus,Citri Reticulatae Pericarpium,Carapax Trionycisl,Massa Medicata Fermentata,Pseudostellaria heterophylla,Lysimachia christinae Hance,Perilla seed,Oyster,keel,Buddhist hand,turmeric,Hawthorn and malt.4.Professor Xie used the four qi of Chinese medicine with higher frequency statistics of warm,cold and flat medicines.The five tastes of Chinese herbal medicines are mostly bitter,sweet and pungent,and the herbal medicines attributed to the spleen,lung,stomach and liver meridians are the most frequent.5.Professor Xie’s commonly used Chinese medicine efficacy is based on deficiency tonics,qi regulators,digestive tonics,water-releasing and dampness-permeating,heat-clearing,dampness-transforming,and blood-activating and blood-stasis-removing.6.By analyzing the data of high-frequency drugs(frequency≥20%),a total of 12 pairs and 7 drug combinations were obtained for Professor Xie’s commonly used drugs.Conclusion:1.Professor Xie Jingri treats patients with hepatic fibrosis,the pathological factors are mainly liver depression,spleen deficiency,dampness and heat,phlegm,blood stasis and kidney deficiency,and summarizes the main pathological mechanisms of liver depression and spleen deficiency,dampness and heat accumulation,and phlegm and stasis interconnection.2.Professor Xie Jingri treats this disease with warm and cold,bitter,sweet and pungent flavors as well as spleen,lung,stomach and liver meridians.The frequently used core medicines include Atractylodes macrocephala,Bupleurum,Astragalus membranaceus,Citri Reticulatae Pericarpium,Carapax Trionycisl,Massa Medicata Fermentata,Pseudostellaria heterophylla,Lysimachia christinae Hance,Perilla seed,Oyster,keel,Buddhist hand,turmeric,Hawthorn and malt.3.Professor Xie Jingri treats hepatic fibrosis by tonifying the liver,strengthening the spleen,and invigorating the kidney and blood as the basic method.