The Study Of Whole Body Bone Imaging Combined With Tumor Markers,P1NP And Bone Mineral Density In The Diagnosis Of Bone Metastases From Prostate Cancer

Objective The incidence of prostate cancer is increasing year by year.In order to understand the distribution of prostate cancer bone metastases in various parts of the body,this study explored the semi-quantitative indicators of bone imaging,prostate cancer tumor markers,procollagen type 1 amino-terminal peptide(procollagen type 1amino-terminal peptide)The diagnostic value of terminal pro-peptide,P1NP)and bone mineral density in prostate cancer bone metastasis.It is expected that it can provide more meaningful solutions for the diagnosis of clinically diagnosed prostate cancer bone metastases.Methods A retrospective study was performed on 183 patients with prostate cancer diagnosed pathologically and with complete clinical data in the Third Clinical Medical College of Inner Mongolia Medical University from January 2019 to December 2021.According to the results of SPECT/CT bone scintigraphy,the patients who met the inclusion criteria were divided into a prostate cancer bone metastasis group and a prostate cancer non-metastasis group,including 104 cases in the metastasis group and 79 cases in the non-metastasis group.Gleason score,free prostate specific antigen(f PSA),total prostate specific antigen(t PSA),and ratio of free prostate specific antigen to total prostate specific antigen(free-to-Total prostate specific antigen ratio(f/t PSA),P1 NP,lumbar spine bone mineral density,femoral bone mineral density,and whole body bone mineral density were summarized.;Draw ROC curve for semi-quantitative indexes of bone imaging to analyze the diagnostic accuracy of osteogenic bone metastases.Results The bone metastases of prostate cancer are mainly sacral,lumbar,thoracic and pelvic.Univariate statistical analysis was performed on patients with prostate cancer bone metastasis.The results showed that there were significant differences in Gleason score,f PSA,t PSA,P1 NP and lumbar bone mineral density between prostate cancer metastasis group and non-metastasis group(P<0.05);f/t PSA,femoral bone density There was no significant difference in density and whole body bone mineral density between groups(P>0.05).Logistic multivariate regression analysis showed that Gleason score,f PSA,t PSA,P1 NP,and lumbar spine bone mineral density all affected the occurrence of prostate cancer bone metastasis(P<0.05).The semiquantitative index of radionuclide bone imaging T/NT(T refers to the average radioactive count in the lesion area,NT refers to the average radioactive count in the non-metastatic tissue)in the metastatic lesions(1.89,1.16-4.28,median,minimummaximum value))and non-metastatic lesions(3.47,2.18-17.98)were significantly different(P < 0.05),and the area under the ROC curve was 0.887.When T/NT was3.11,the sensitivity and specificity in diagnosing prostate cancer bone metastasis were The degrees are 89.1% and 75.4%.Conclusion The bone metastases of prostate cancer are mainly the axial bone and pelvis.Gleason score,P1 NP,f PSA,t PSA and lumbar bone mineral density are all risk factors for the diagnosis of bone metastases from prostate cancer.Bone imaging semiquantitative analysis index T/NT has a high value in the diagnosis of bone metastasis of prostate cancer,and the diagnostic accuracy is the highest when T/NT is 3.11.