| Objective By studying the correlation between red blood cell distribution width(RDW),platelet distribution width(PDW)and left ventricular hypertrophy(LVH)in patients with essential hypertension,and analyzing RDW,PDW Whether it can be used as a predictor of LVH in patients with essential hypertension aims to provide new ideas and theoretical basis for effective early clinical prediction of LVH.Methods Using a retrospective study method,160 patients with essential hypertension who met the inclusion criteria from December 2020 to December 2021 in the outpatient department or inpatient department of Cardiovascular Medicine,People’s Hospital of Inner Mongolia Autonomous Region were selected.All patients underwent echocardiography.The left ventricular mass index(LVMI)was calculated by the Devereux correction formula.According to the diagnostic criteria of LVH,eligible patients with essential hypertension were divided into hypertension without left ventricular hypertrophy group(NLVH group).)95 cases and 65 cases of hypertension with left ventricular hypertrophy group(LVH group),the general information,medical history,blood routine,related biochemical indicators,echocardiography and 24-hour ambulatory blood pressure(24h ABPM)monitoring indicators of all patients were collected and recorded.,using SPSS21.0 software for statistical processing and analysis of all data.Results1.Comparison between LVH group and NLVH group: RDW in LVH group was12.749%±0.881%,PDW was 14.000(12.150,14.450)%,RDW in NLVH group was12.125%±0.669%,PDW was 12.200(11.900,12.500)%,RDW and PDW in LVH group were significantly higher than those in NLVH group,and the difference was statistically significant(P<0.05).2.Multivariate binary logistic regression analysis showed that: RDW(OR: 2.675,95%CI: 1.502-4.766,P<0.05),PDW(OR: 2.216,95%CI: 1.494-3.287,P<0.05),ultra-high High-sensitivity C-reactive protein(hs CRP)(OR: 1.393,95%CI: 1.004-1.932,P<0.05),24hour-systolic blood pressure(24h-SBP)(OR: 1.126,95%CI: 1.026-1.284,P<0.05)was an independent risk factor for the occurrence of LVH in hypertension.3.The receiver operating curve(ROC)analysis showed that the area under the curve(AUC)of RDW for predicting the occurrence of LVH was 0.725(95% CI: 0.642-0.807,P<0.001).The optimal cut-off value was12.550,and its sensitivity for predicting LVH in hypertension was 58.5% and the specificity was 77.9%;the AUC of PDW was 0.738(95% CI: 0.647-0.830,P<0.001),when PDW’s AUC was 0.738(95% CI: 0.647-0.830,P<0.001).When the optimal cutoff value was 13.350,the sensitivity was 63.1% and the specificity was 92.6%;the AUC of hs CRP was 0.697(95% CI:0.606-0.788,P<0.001),when the optimal cutoff value of hs CRP was 1.955,the sensitivity The specificity was 70.8% and the specificity was 84.2%;further combined indicators were used to predict the value of left ventricular hypertrophy in hypertension.The results showed that the combined AUC of RDW and PDW was 0.807(95% CI: 0.735-0.880,P<0.001).When 24.576 was taken as the best cut-off value for the combination of RDW and PDW,the sensitivity was 69.2% and the specificity was 88.4%;the AUC of the combination of RDW,PDW and hs CRP was 0.838(95% CI: 0.774-0.903,P<0.001),When RDW,PDW and hs CRP were combined to take 25.459 as the best cut-off value,the sensitivity was 72.55% and the specificity was 94.7%.Conclusion 1.RDW,PDW and LVH are closely related to patients with essential hypertension.2.Increased levels of RDW,PDW and hs CRP are independent risk factors for LVH in hypertension.3.The combined detection of RDW,PDW and hs CRP has a good predictive value for LVH in hypertension.In clinical work,the detection of RDW,PDW and hsCRP can be used to evaluate and prevent target organ damage. |
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