Effect Of Procalcitonin And C-reactive Protein On Prognosis Of Patients With Cerebral Edema Secondary To Cerebral Infarction In Xining Area

Objective The purpose of this study was to monitor the level of procalcitonin and C reactive protein in patients with cerebral edema secondary to ischemic stroke admitted to EICU,and to evaluate the effect of procalcitonin and C-reactive protein on the prognosis of patients with cerebral edema secondary to cerebral infarction in Xining area.Methods The cases collected in this study were patients with cerebral edema secondary to ischemic stroke who entered EICU within 48-72 hours from November2020 to November 2021 in the Affiliated Hospital of Qinghai University.Obtain the basic information of patients(age,gender,blood pressure,triglyceride level,smoking history,drinking history,etc.),the PCT and CRP levels of 7 days were collected after admission and the average values were taken.The prognostic results were collected 90 days after discharge.According to the prognostic results,they were regrouped by death or survival.The prognosis of patients was evaluated by m RS score after 90 days of telephone follow-up after discharge.Finally,the prediction ability of two serum markers to the prognosis of patients was evaluated by drawing ROC curve.Result 1.A total of 101 cases were collected,including 47 cases in the death group and 54 cases in the survival group.2.General information inter-group comparison.Chisquare test was used for counting data,and group-sample t-test was used for measurement data.The results showed that there were significant differences in age,triglyceride level,smoking history and drinking history between the death group and the survival group(P < 0.05).There was no significant difference in gender and blood pressure between survival group and death group(P > 0.05).3.Comparison of PCT and CRP levels.The levels of serum PCT and CRP in death group and survival group were tested by Mann Whitney U test.CRP: z =-2.396,P = 0.017 > 0.001.There was no obvious difference between the two groups.PCT: z =-4.196,P = 0.000 < 0.001.There was obvious difference between two groups.Therefore,compared with CRP,PCT is more persuasive in reflecting the prognosis of patients.4.Binary logistic regression analysis was performed on two groups of data.The regression coefficient of PCT was0.161(P = 0.000 < 0.05),and the regression coefficient of CRP was 0.077(P = 0.007< 0.05).Therefore,Both PCT and CRP value indicated significance.5.Draw the ROC curve.Taking the patient’s death as the observation index,the result is that the AUC of PCT is 0.744,the AUC of CRP is 0.639.The sensitivity of PCT is 68.10%,the specificity is 81.25%.The sensitivity of CRP is 65.95%,the specificity is 58.62%.Therefore,the practical value of PCT is higher than that of CRP.6.The m RS was performed and summarized among surviving group in this study.The results are as follow: 0 point(3.7%)1 point(27.8%)2 points(27.8%)3 points(25.9%)4 points(11.1%)5 points(3.7%).According to the criteria issued by American Heart Association Consensus Recommendations from Stroke Therapy Academic Industry Roundtable XI.0-1 point was considered as good prognostic result.2-3 was considered as moderate.(In this scale,patients who scored 3 points can live independently,but cannot live independently over 1 week)4-5 was considered as poor outcome.The patients who scored 3 points can live independently for no more than 1 week,Therefore,in this study,the patients who scored 0-3 points were considered as good outcome,which account for 85.2%.In summary,the prognostic of surviving cerebral edema secondary to ischemic stroke patients received good outcome.Conclusions Comparing to CRP,PCT has higher specificity and sensitivity in predicting the prognostic of the cerebral edema secondary to cerebral infarction.