Clinical Observation Of Local Injection Platelet-rich Plasma Combined With Sophora Flavescens Lotion On Postoperative Wound Of Fistulectomy

Objective: Based on the theory of Chinese medicine and modern medical research,to observe the clinical efficacy of local injection of platelet-rich plasma combined with sitz bath of bitter ginseng lotion on the postoperative trauma of low simple anal fistula with damp heat injection,to explore whether local injection of platelet-rich plasma combined with sitz bath of bitter ginseng lotion can accelerate the healing of trauma by reducing trauma pain,exudate and promoting the growth of granulation tissue,and to explore new ideas for the treatment of postoperative trauma of anal fistula.To explore new ideas for the treatment of postoperative trauma.Methods: A total of 90 patients with damp-heat-infused low simple anal fistula admitted to the Department of Anorectal Medicine,Qifoshan Hospital,Shandong Province,between November 2021 and November 2022 were randomly divided into three groups: 30 patients each in the experimental group,control group 1 and control group 2.The three groups were treated with the same preoperative preparation and fistulotomy,and the postoperative dressing was changed daily.In the experimental group,platelet-rich plasma was injected into the wound surface and a daily sitz bath with bitter ginseng lotion was used after surgery;in the control group 1,only a daily sitz bath with bitter ginseng lotion was used;in the control group 2,platelet-rich plasma was injected into the wound surface and the wound surface was washed with saline daily.The platelet-rich plasma was injected before the end of surgery;the bitter ginseng lotion sitz bath was given once a day in the morning and once in the evening,and a course of medication was given for 1 week,for a total of 2 courses of treatment,and the results of the three regimens were observed and compared.Results: A total of 90 patients with low simple anal fistula of damp-heat infusion type were included in this study,and finally 86 cases completed clinical observation and were included in the statistics.One case fell off in the test group,two cases fell off in control group 1,and one case fell off in control group 2,with an overall rate of 4.44%.The gender,age distribution and initial trauma area of the patients in the three groups were not statistically different and comparable,and the results of the study were analyzed as follows:(1)Trauma healing rate: The trauma healing rate of the test group was higher than that of control group 1 and control group 2 at 7d and 14 d postoperatively(P<0.05);the trauma healing rate of control group 1 and control group 2 at 7d postoperatively was not statistically different(P>0.05).(2)Trauma pain scores: In the comparison of pain scores at 7d and 14 d postoperatively,the pain scores of the test group were lower than those of control group 1 and control group2(P<0.05),and there was no significant difference between control group 1 and control group 2(P>0.05).(3)Wound exudation: In the comparison of wound exudation scores at 7d and 14 d after surgery,the test group was lower than both control group 1 and control group 2(P<0.05),and control group 1 was also lower than control group 2(P<0.05).(4)Wound granulation growth: there was no significant difference in granulation growth between the three groups at 7d postoperatively(P>0.05);in the comparison at 14 d postoperatively,the test group had lower granulation growth scores than control group 1(P<0.05),and control group 1 had lower growth scores than control group 2(P<0.05).(5)Wound healing time: The wound healing time of the test group was shorter than that of control group 1 and control group 2(P<0.05).(6)Clinical efficacy: the final efficacy of the test group was better than that of control group 1(P<0.05),and control group 1 was better than control group 2(P<0.05).Conclusion: Local injection of platelet-rich plasma combined with bitter ginseng lotion in sitz bath for the treatment of post-anal fistula excision wounds can relieve wound pain,reduce exudate,accelerate granulation growth and speed up wound healing,and its efficacy is better than that of bitter ginseng lotion alone and local injection of PRP group.