| BackgroundThe prognostic value of albumin/alkaline phosphatase ratio(AAPR)in patients with hepatocellular carcinoma(HCC)remains controversial.This meta-analysis aims to evaluate the prognostic role of AAPR in patients with HCC.MethodsThe databases of Web of Science,Embase,Cochrane Library and PubMed were comprehensively searched from inception to December 30th,2022.Pooled hazard ratio(HR)and 95%confidence interval(CI)were calculated with Stata 16.0 software for the assessment of the relationship between AAPR and overall survival(OS)as well as recurrence-free survival(RFS)in patients with HCC.ResultsA total of 2634 patients from 12 cohorts were included in this meta-analysis.The pooled results showed that lower AAPR predicted poorer OS(HR:2.02,95%CI:1.78-2.30).Similarly,pooled results demonstrated that lower AAPR also predicted poorer RFS(HR:1.88,95%CI:1.37-2.57).The heterogeneity for RFS by multivariate analytic results and the publication bias for OS existed,however,the subgroup analysis,meta-regression analysis as well as adjustment using trim-and-fill analysis confirmed an association between AAPR and OS as well as RFS.ConclusionsThis meta-analysis proves that lower AAPR in patients with HCC predicted inferior survival outcomes,and AAPR might be a promising indicator for the prognosis of HCC.BackgroundOur study aimed to explore the prognostic value of the aspartate aminotransferase-platelet ratio index(APRI)and to develop a new nomogram for patients with HCC who experience late recurrence after radiofrequency ablation(RFA).To date,no study has explored the value of APRI for assessing the late recurrence of HCC after RFA.Materials and MethodsThe prognostic value of APRI was evaluated and validated in our multicentre retrospective analysis.A total of 466 HCC patients undergoing RFA were reviewed as a training cohort,and 234 HCC patients were included in the external validation cohort.The nomogram was built based on significant prognostic factors in a multivariate analysis and validated in the external validation cohort.ResultsThe cut-off APRI score was 0.78,and it appropriately discriminated between low-and high-risk groups for late recurrence in HCC patients.The cumulative recurrence-free survival rates of the low-risk group were significantly higher than those of the high-risk group(P<0.001),according to the Kaplan-Meier curves.Late recurrence in HCC patients after RFA was associated with APRI,sex,and multiple tumours.The nomogram based on potential risk factors(APRI score,sex,and multiple tumours)as indicated by multivariate Cox regression analysis showed good discrimination and calibration in the training and external verification groups.ConclusionsThe APRI score is a feasible independent prognostic factor for the late recurrence of HCC after RFA.The proposed nomogram could aid clinicians in following disease progression and providing tailored therapy for patients. |
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