| Objective: Medical records of patients hospitalized with liver cirrhosis by Liaoning Provincial People’s Hospital, explore the meaning of APRI, just aspartate aminotransferase(AST) and platelet count(PLT) ratio changed in varying degrees of liver cirrhosis, in order to provide a new evidence for clinical diagnosis and assess the prognosis of liver cirrhosis.Methods: Strictly in accordance to the inclusion criteria and exclusion criteria to select cirrhotic patients 68 cases of cirrhosis, including cirrhosis after hepatitis B virus 33 cases, cirrhosis after hepatitis C virus 18 cases, alcoholic cirrhosis 17 cases in the Department of Gastroenterology, Department of Infectious Diseases of Liaoning Province People’s Hospital from November 2013 to October 2014, and compared with the same period Liaoning Province People’s Hospital Medical Center 26 healthy cases of control group. Collected clinical data for each study, patients with cirrhosis were grouped according to the Child-Pugh classification standards and whether with the complication of upper gastrointestinal bleeding. Calculate APRI values for each group.Application of SPSS 17.0 statistical software for analysis, measurement data showed normal distribution are expressed as the mean ± standard deviation, compare APRI value changes in varying degrees of liver cirrhosis patients, analyze the correlation between APRI and liver fibrosis index, Hyaluronic acid(HA),and contrast the differences APRI in cirrhotic patients who with gastrointestinal bleeding or not.Results: The data show that in addition to cirrhosis HA, the rest of the set of data in line with normal distribution. T he difference between the cirrhosis group and the control group for age or sex was not statistically significant(P> 0.05), comparable. APRI values??cirrhosis group and the control group APRI values ??were 2.18 ± 1.32 and 0.31± 0.09, significantly higher than the control group APRI cirrhosis group(P <0.01); A, B,C three groups APRI were 1.32 ± 0.48, 2.53 ± 0.91,3.42 ± 1.69, cirrhosis among the three groups were statistically significant(P <0.01, P <0.05); In HA <100 ng / ml of the normal range, cirrhosis HA content of 299.00 ± 218.83 ng / ml, it can be said HA in cirrhotic patients was significantly elevated; A, B, C three groups of HA were 148.65 ±70.21 ng / ml, 301.46 ± 157.10 ng / ml, 587.08 ± 189.39 ng / ml, Cirrhosis HA levels within the group were incremental changes, the difference was statistically significant(P<0.01); By Spearman bivariate correlation analysis, we arrived at APRI and HA significantly correlated(r = 0.886, P <0.01); APRI bleeding in cirrhotic group and not bleeding group were 3.13 ± 1.56,1.70 ± 0.86, between the two groups also have significant differences, and the results were statistically significant(P <0.01).Conclusion: With exacerbations, ARPI in liver cirrhotic patients is increasing, showing A <B <C incremental changes in Child-Pugh classification. There’s a good correlation between APRI and HA. The liver cirrhosis patients with high APRI likelihood of upper gastrointestinal bleeding much. ARPI can be used as a new indicator to assess the severity of liver cirrhosis and prognosis. APRI level and degree of liver damage are closely related. Emphasising on monitoring the APRI level fluctuation in liver cirrhosis patient has important clinical value for diagnosis, treatment, prognosising the outcome of the disease and reducing the incidence of upper gastrointestinal bleeding. |
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