Clinical Observation Of Huatan Yixin Formula In The Treatment Of Coronary Heart Disease Stable Angina Pectoris (Phlegm-Stasis Type) With Insomniaand Its Effect On Serum IL-6 Level

Objective: To observe the clinical efficacy and safety of the treatment of stable angina pectoris in coronary heart disease(phlegm-stasis type)with insomnia with the help of the Huatan Yixin Formula,and to objectively evaluate the effectiveness of the Huatan Yixin Formula in relieving the symptoms of angina pectoris,improving the Chinese medicine evidence score and improving the sleep quality of patients.At the same time,the effect of this formula on serum IL-6 level was investigated in order to provide new ideas for the treatment of stable angina pectoris in coronary heart disease.Methods: Sixty patients with stable angina pectoris with insomnia in coronary heart disease(phlegm-stasis type)who met the inclusion criteria were selected and randomly divided into a control group and an experimental group,with 30 cases in each group.The control group was treated with conventional Western medicine,and the experimental group was treated with Huatan Yixin Formula on the basis of the control group,treatment for 4 weeks.Before and after the treatment of the two groups,the efficacy of angina pectoris,nitroglycerin stopping reduction rate,the efficacy of electrocardiogram,the efficacy of Chinese medical evidence,the score of Seattle Angina Quetionnaire(SAQ),the score of Pittsburgh Sleep Quality Index(PSQI)and the change of serum IL-6 level were observed.Finally,all acquired data were entered into SPSS 25.0 software for statistical analysis of the final results.Results:1.Angina pectoris efficacy: both groups could effectively improve angina pectoris symptoms compared before and after treatment,and the improvement efficiency of the test group was better than that of the control group(P < 0.05).2.Nitroglycerin stopping reduction rate: Both groups could effectively reduce the number of nitroglycerin tablets before and after treatment,and the stopping rate of the test group was better than that of the control group(P <0.05).3.Electrocardiogram efficacy: Both groups could effectively improve the electrocardiogram changes before and after treatment,and the improvement efficiency of the test group was better than that of the control group(P < 0.05).4.Chinese medicine evidence efficacy: before and after treatment compared to both groups could effectively improve the Chinese medicine evidence score,Chinese medicine evidence efficacy,the test group was better than the control group(P < 0.05).5.Seattle Angina Questionnaire score: compared with both groups before and after treatment,both groups could effectively improve the SAQ score,and the test group was better than the control group(P < 0.05).6.Pittsburgh Sleep Quality Index scale score: both groups could effectively improve PSQI score before and after treatment,and the test group was better than the control group(P < 0.05).7.Serum interleukin IL-6 level: compared before and after treatment,both groups could effectively reduce serum interleukin IL-6 level,and the test group was better than the control group(P < 0.05).Conclusion:1.Huatan Yixin Formula can effectively improve the symptoms of angina pectoris in patients with stable angina pectoris with coronary heart disease(phlegm-stasis type)with insomnia,improve the efficacy of angina pectoris and electrocardiogram,and reduce the number of tablets of nitroglycerin used.2.Huatan Yixin Formula can effectively reduce the TCM symptom scores of patients with stable angina pectoris with coronary heart disease(phlegm-stasis type)with insomnia,improve the symptoms of TCM symptoms and enhance the efficacy of TCM treatment.3.Huatan Yixin Formula can effectively improve the scores and quality of life of patients with stable angina pectoris in coronary heart disease(phlegm-stasis type)with insomnia on the Western Atlas Angina Scale.4.Huatan Yixin Formula can effectively reduce the Pittsburgh Sleep Quality Index score and improve sleep quality in patients with stable angina pectoris with coronary heart disease(phlegm-stasis type)with insomnia.5.Huatan Yixin Formula can effectively reduce the serum IL-6 level in patients with stable angina pectoris with coronary heart disease(phlegm-stasis type)with insomnia.