Study On The Correlation Between Antiphospholipid Antibody Level And Adverse Pregnancy Outcome In Early Pregnancy

Objective:To investigate the correlation between the level of antiphospholipid antibodies(aPLs)in early pregnancy and pregnancy complications/complications and adverse pregnancy outcomes.Methods: Patients in the first trimester of pregnancy who visited the Obstetrics clinic of the Second Affiliated Hospital of Xinjiang Medical University from September 2020 to February 2023 were selected and divided into four groups according to the detection results of aPLs in the first trimester.Group A was control group(150 cases): a CL antibody and anti-β2-Gp1 antibody were negative;group B(100 cases): only anti-β2-Gp1 antibody was positive;group C(55 cases): only a CL antibody was positive;group D(72 cases): a CL antibody and anti-β2-Gp1 antibody were both positive.Patients found to be positive for aPLs in early pregnancy were given medication and antibodies were rechecked every 12 weeks until negative or delivery.According to the time of aPLs antibody conversion,pregnant women were divided into 28 weeks before the antibody conversion group and 28 weeks after the antibody conversion group.The level of aPLs in the early stage of pregnancy,the changes in the course of pregnancy,the complications/complications of this type of pregnant women,pregnancy outcomes and neonates and other related clinical data were analyzed,and statistical analysis was conducted.Results: 1.The baseline level of general data was consistent among the four groups of pregnant women(P > 0.05),which could be compared.2.Compared with the pregnancy outcome of the four groups,the incidence of abortion in group D was significantly higher than that in the other three groups,with statistical difference(P<0.05),while the incidence of premature delivery,stillbirth and live birth had no statistical difference(P > 0.05).3.In the comparison of pregnancy complications/complications among the four groups in the live birth group,the incidence of hypertensive diseases during pregnancy in group D was significantly higher than that in the other three groups,with statistical difference(P < 0.05),while the other pairings showed no statistical significance.There was no significant difference in gestational diabetes mellitus,pregnancy with hypothyroidism,anemia during pregnancy and postpartum hemorrhage(P>0.05).4.There were no significant differences in macrosomia,intrauterine distress,intrauterine growth restriction,premature rupture of membranes and oligohydramnios in the live birth group(P > 0.05).5.There were no significant differences in neonatal body weight,Apgar,amniotic fluid volume,blood loss and gestational age in the live birth group(P>0.05).6.There were no significant differences in the ultrasound indexes(S/D)of the third trimester in the live birth group(P >0.05).There was statistical difference in amniotic fluid index(P<0.05),pairwise comparison between group A and group B,group B and group D had statistical difference(P<0.05);There was A statistical difference in the placental maturity of the four groups(P<0.05).The incidence of placental maturity II in group C and D was more than 70%,the incidence of placental maturity II in group A was relatively low,and the placental maturity III in group B was 12.7%.7.In the live birth group,there was no statistical difference between the time of antibody conversion to negative after treatment and the incidence of fetal intrauterine growth restriction and stillbirth(P > 0.05),while there was statistical significance between the time of antibody conversion to negative and the incidence of gestational hypertension,gestational diabetes and preterm birth(P<0.05).The incidence of gestational diabetes was higher in the antibody conversion to negative before 28 weeks.However,the incidence of preterm birth and hypertensive disease during pregnancy was higher in the group whose antibody turned negative after 28 weeks.Conclusion: The incidence of anti-β2-GP1 antibody positive in early pregnancy was significantly higher than that of a CL antibody and both antibodies positive in patients with adverse pregnancy history or threatened abortion in this pregnancy.Anti-β2-gp1 antibody and a CL antibody can cause certain adverse pregnancy outcomes in early pregnancy,and the incidence of adverse pregnancy outcomes in double-yang and anti-β2-GP1 antibody is higher than that in single-yang and negative pregnant women.The earlier the antibody turns negative in pregnant women who are positive for this antibody for clinical intervention,the lower the incidence of pregnancy-related complications and adverse pregnancy outcomes.