Correlation Of Blood Eosinophil Levels With The Efficacy Of Glucocorticoids In Patients With AECOPD

Objective:To investigate the relationship between blood eosinophil levels and the efficacy of glucocorticoids in patients with acute exacerbation of chronic obstructive pulmonary disease.Methods: One hundred and twenty-two patients diagnosed with acute exacerbation of chronic obstructive pulmonary disease who were hospitalized at the Fifth Affiliated Hospital of Xinjiang Medical University from September 1,2020 to December 31,2022 were retrospectively selected and divided into positive group(EOS %≥2%)and negative group(EOS %<2%)based on the eosinophil percentage in routine blood drawn within 24 hours of admission,with 2% set as the grouping cut-off value.During the hospitalization period,in addition to conventional treatment,all patients were given budesonide suspension 2 mg nebulized inhalation three times a day,and the neutrophil count(N),calcitoninogen(PCT),C-reactive protein(CRP),arterial partial pressure of oxygen(Pa O2),arterial carbon dioxide(Pa CO2),length of hospitalization and the Chronic Obstructive Lung Assessment Test(CAT score),modified version of the British Medical Research Council Dyspnea Questionnaire(m MRC score)before and after treatment.Results:There were no significant differences between the two groups in terms of baseline information including patients’ gender,age,BMI,whether they smoked,disease duration,and comorbidities(P > 0.05).Before treatment,N,CRP,Pa O2,Pa CO2,m MRC score,CAT score: no significant difference between the two groups(P > 0.05);after treatment,there was no difference in N,CRP,PCT between the two groups,and Pa O2,Pa CO2,m MRC score,CAT score between the two groups:significant difference between the positive and negative groups(P < 0.05);there was a significant difference in the length of stay between the two groups(P > 0.05).EOS%was positively correlated with ΔPCT,ΔPa O2,ΔPa CO2 score and Δm MRC score(P <0.05),and negatively correlated with length of hospitalization(P > 0.05).Conclusion:Compared with patients with low peripheral blood eosinophils,patients with high peripheral blood eosinophils were more sensitive to glucocorticoid therapy,had better treatment effect,shorter hospitalization days and more obvious improvement of clinical symptoms;the level of blood eosinophils correlated with the efficacy of glucocorticoids in patients with AECOPD;suggesting that the application of inhaled glucocorticoids with high blood eosinophils is effective in the treatment of patients with AECOPD.