The Relationship Between Systemic Immune-Inflammation Index And Coronary Slow Flow Phenomenon

Objective: The purpose of our study was to evaluate the mechanism of systemic immune-inflammation index(SII)in coronary slow flow phenomenon(CSFP)and its predictive value for CSFP.Methods: This study retrospectively collected patients admitted to the People’s Hospital of Liaoning Province with complaints of chest pain and underwent coronary angiography(CAG)which showed normal arteries between October 2020 and January2022.According to the inclusion and exclusion criteria,256 patients were enrolled in this study including 89 patients with CSFP,and 167 controls.The control group was composed of patients who underwent CAG in the same study period.Baseline data,laboratory indicators and CAG data were collected and compared between the two groups.SII was calculated by blood sampling tests.The specific formula is obtained by multiplying the total number of peripheral blood platelets(P)and neutrophils /lymphocytes(N / L)before operation.Univariate and multivariate regression analyses were performed to identify the risk factors influencing the occurrence of CSFP.The receiver operating characteristic(ROC)curve was plotted to assess the ability of SII to predict the occurrence of CSFP and the optimal cut-off value.Results: 1.The SII level(409.7±17.7 VS 396.7±12.7,P<0.001)was significantly higher in the CSFP group compared to the control group,and the value of SII increased with the number of vessels in which CSFP occurred.2.In the Spearman correlation analysis,SII was significantly and positively correlated with the mean thrombolysis in myocardial infarction frame count(m TFC)(r=0.624,P<0.001).The multivariate logistic regression analysis suggested that SII/10 was an independent predictor of CSFP(OR: 1.739,95%CI:1.408-2.148,P<0.001).i.e.,each 10-unit increase in SII was associated with a 73.9% increase in CSFP prevalence in the study population.In the ROC analysis,SII was the best predictor of CSFP at 404.29 with an area under the curve(AUC)of 0.715,a sensitivity of 67.4% and a specificity of 71.9%(95%CI:0.655-0.769,P<0.001).Conclusion: The SII level was significantly and independently related to the occurrence of CSFP.Moreover,its value increased as the number of involved vessels increased.SII as a mediator of inflammation can predict the occurrence and severity of CSFP.