| Objective: To observe the changes of TCM syndrome score,24-hour ambulatory blood pressure,total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),blood homocysteine(Hcy)and other indexes in the treatment of patients with blood stasis hypertension with Huoxue Antihypertensive Formula combined with Western medicine,and to evaluate the clinical efficacy and safety of Huoxue Antihypertensive Formula.Methods: 70 cases were included in this study and divided into control group and observation group,35 cases in each group.The control group was treated with oral valsartan amlodipine tablets,and the observation group was treated with Huoxuejiangya prescription on the basis of the control group,the course of treatment was 4 weeks.TCM syndrome scores,blood pressure in the office,24-hour mean systolic and diastolic blood pressure in ambulatory blood pressure,blood pressure load,circadian blood pressure rhythm,TC,LDL-C and Hcy were analyzed and compared between the two groups before and after treatment.Results:1.Before treatment,age,gender,smoking history,drinking history,family history of cardiovascular disease,24-hour ambulatory blood pressure,TCM syndrome score,TC,LDL-C,Hcy and other aspects were compared between the two groups,showing no statistical significance(P > 0.05).2.Comparison of the curative effect of TCM syndromes: After treatment,the curative effect of TCM syndromes in the observation group was better than that in the control group,and the difference was statistically significant(P < 0.05).3.Comparison of TCM syndrome score: After treatment,TCM syndrome score of the two groups decreased compared with that before treatment,and the improvement of TCM syndrome score of the observation group was better than that of the control group(P < 0.05).4.Comparison of TCM single symptom scores: Symptom scores of vertigo,headache such as tingling,dry mouth,forgetfulness,insomnia,palpitation and tinnitus in the observation group after treatment were improved compared with those before treatment(all P< 0.05);Symptom scores of vertigo,headache such as tingling and insomnia in control group were improved compared with those before treatment(all P < 0.05),while symptom scores of palpitation,tinnitus,dry mouth and forgetfulness were not significantly improved compared with those before treatment(all P > 0.05).After treatment,the improvement of symptom scores of vertigo,headache such as stinging,dry mouth,forgetfulness,insomnia,palpitation and tinnitus in the observation group was better than that in the control group(all P < 0.05).5.Comparison of blood pressure in the consulting room after treatment: Blood pressure in the two groups after treatment was improved compared with that before treatment(all P <0.05);After treatment,the blood pressure of the observation group was lower than that of the control group(P < 0.05).The rate of blood pressure reaching the standard after treatment in the observation group was higher than that in the control group,and the difference was not statistically significant(P > 0.05).6.Comparison of ambulate blood pressure: After treatment,the 24-hour average systolic blood pressure and average diastolic blood pressure of the two groups decreased compared with that before treatment(all P < 0.05),and the decrease of blood pressure of the observation group was better than that of the control group(all P < 0.05).The improvement of blood pressure load and circadian rhythm in the two groups after treatment was better than that before treatment(all P < 0.05),and the improvement of blood pressure load and circadian rhythm in the observation group after treatment was better than that in the control group(all P< 0.05).7.Comparison of TC and LDL-C levels: After treatment,the levels of TC and LDL-C in the two groups were lower than before treatment(all P < 0.05),and the reduction of TC and LDL-C in the observation group was better than that in the control group after treatment(P <0.05).8.Comparison of Hcy: There was no statistically significant difference in the Hcy level of the control group before and after treatment(P > 0.05).The Hcy level of the observation group after treatment was lower than that before treatment(P < 0.05),and the Hcy level of the observation group after treatment was better than that of the control group(P < 0.05).9.Safety comparison: No adverse reactions or allergies related to the drugs in this subject occurred in the 70 patients during treatment.Conclusion: Huoxue Antihypertensive Formula formula can effectively improve the TCM syndrome,blood pressure level,TC,LDL-C,Hcy and other indicators of patients with blood stasis type hypertension,with good clinical efficacy and safety,worthy of clinical promotion and application. |
