| Objective:To observe the curative effect of Ditan Huoxue Decoction combined with Western medicine in the treatment of phlegm and blood stasis type essential hypertension,and observe the changes of blood pressure in the office,blood pressure in the family,24-hour ambulatory blood pressure,TCM syndrome,blood lipids,whole blood viscosity,etc.The treatment group and the control group were compared.Methods:Select 60 patients with phlegm and blood stasis mutual junction,patients with essential hypertension(eh)were randomly divided into control group and treatment group(30 cases each,both groups on the basis of low salt low fat diet,control group oral benzene sulfonic acid amlodipine(collaterals live happy),on the basis of control group and treatment group Ditan Huoxue Decoction(bravery nanxing,pinellia,acid-insoluble ash,poria cocos,dried tangerine or orange peel,stone calamus,bamboo shavings,angelica dahurica,salvia miltiorrhiza,red paeony root,peach kernel,rhizoma ligustici wallichii,safflower,radix cyathulae,ginger,jujube),two groups as a course of 4 weeks,the continuous treatment of 8 weeks.Observed two groups of patients with blood pressure,blood lipids including total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),whole blood viscosity,including plasma viscosity(XTND),hematocrit(HCT),whole blood highshear relative index(GQXD),whole blood low shear relative index(DQXD),whole blood reductive viscosity:low cut(HDQ),whole blood reductive viscosity:high cut(HGQ),syndromes and other indicators of change and assess the security situation,using statistical software analysis results,combined with the tutor academic thoughts and his own formula of law to analyze its mechanism,the research conclusion.Results:1 Patients with improved blood pressure: comparison of office blood pressure,family self-test blood pressure and ambulatory blood pressure:intra-group comparison,treatment group decreased blood pressure after treatment,data before and after treatment,P <0.05,the difference was statistically significant;blood pressure decreased after treatment in the control group The data before and after treatment,P <0.05,the difference was statistically significant.Comparison between groups,before treatment,compared with the control group,P > 0.05,the difference was not statistically significant;after treatment,the treatment group compared with the control group data,P < 0.05,the difference was statistically significant,the treatment group reduced blood pressure The effect is better.2 blood pressure efficacy: blood pressure efficacy data of the two groups of patients,P >0.05,although there is no statistical difference,but the treatment group antihypertensive effect(93.33%)is still stronger than the control group(86.67%).3 Blood pressure compliance rate: The blood pressure compliance rate data of the two groups were compared,P < 0.05,the difference was statistically significant.The treatment group compliance rate(90%)was better than the control group compliance rate(80%).4 The regulation of blood lipids: In the group,the blood lipids in the treatment group improved after treatment,P <0.05,the difference was statistically significant;the blood lipids did not change significantlyafter treatment,the data before and after treatment,P > 0.05,The difference was not statistically significant.Comparing between groups,before treatment,the treatment group and the control group data,P >0.05,the difference was not statistically significant;after treatment,the treatment group compared with the control group data,P <0.05,the difference was statistically significant,the treatment group improved blood lipids It is better than the control group.5 The whole blood viscosity: Compared with the treatment group,the XTND,HGQ,HDQ,GQXD and DQXD indexes were decreased after treatment.The data before and after treatment were compared,P <0.05,the difference was statistically significant.There was no significant change before and after HCT treatment.Before and after HCT data comparison,P >0.05,the difference was not statistically significant;the blood viscosity index of the control group did not change significantly after treatment,the data before and after treatment,P > 0.05,the difference was not statistically significant.Comparison between groups,before treatment,compared with the control group,P > 0.05,the difference was not statistically significant;after treatment,the treatment group and the control group XTND,HGQ,HDQ,GQXD,DQXD data,P <0.05,the difference Statistically significant,the treatment group improved XTND,HGQ,HDQ,GQXD,DQXD indicators better than the control group,the treatment group and the control group HCT data,P > 0.05,the difference was not statistically significant.6 Single TCM syndrome scores: In the group comparison,the individual TCM syndrome scores of the treatment group decreased after treatment,and the data before and after treatment were compared,P < 0.05,the difference was statistically significant;the individual TCM syndrome scores decreased after treatment in the control group The data before and after treatment,P <0.05,the difference was statistically significant.Comparison between groups,before treatment,compared with the controlgroup,P >0.05,the difference was not statistically significant;after treatment,the treatment group and the control group each individual TCM syndrome score data comparison,P <0.05,the difference is statistically significant Significance,the individual TCM syndrome scores in the treatment group were lower than the control group.7 TCM syndrome total scores: within the group,the total score of TCM syndromes decreased after treatment,the data before and after treatment,P <0.05,the difference was statistically significant;the total score of TCM syndrome after treatment was reduced,treatment Before and after data comparison,P <0.05,the difference was statistically significant.Before comparison between groups,before treatment,the treatment group and the control group data,P > 0.05,the difference was not statistically significant;after treatment,the treatment group and the control group TCM syndrome total score data,P <0.05,the difference was statistically significant The total score of TCM syndromes in the treatment group was lower than that of the control group.8 TCM syndrome efficacy: The two groups of patients with TCM syndrome efficacy data comparison,P < 0.05,the difference was statistically significant,the treatment group TCM syndrome efficacy was higher than the control group.9 Safety comparison: Both groups had adverse reactions,but the degree was light and no treatment was needed.The incidence of adverse reactions was fairer in both groups,P >0.05.Conclusion:1 In terms of antihypertensive,Ditan Huoxue Decoction combined with amlodipine besylate tablets and amlodipine besylate tablets are more advantageous in the treatment of phlegm and blood stasis type essential hypertension.2 Ditan Huoxue Decoction can improve the patient's discomfort,such as dizziness and headache,and improve the quality of life of patients.3 Ditan Huoxue Decoction can effectively improve blood lipid and whole blood viscosity,reduce cardiovascular risk stratification,and bring benefits to patients with cardiovascular and cerebrovascular diseases.4 In the application process,the incidence of adverse reactions and side effects is low.Ditan Huoxue Decoction combined with amlodipine besylate tablets is superior to ampicillin besylate tablets in the treatment of sputum-associated essential hypertension. |
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