Clinical Observation Of Self-Designed Yiqi Huoxue Anshen Prescription In The Treatment Of Senile Chronic Heart Failure (Qi Deficiency And Blood Stasis Type) With Insomnia

Research Objectives:To observe the clinical effect and safety of self-improvement Qi Vital Blood Safety Fo rmula for chronic heart failure and insomnia in old age.Research methods:Seventy-two patients who met the inclusion criteria were randomly divided into two g roups,36 cases in each group.On the basis of routine Western medicine treatment,the cont rol group was added with Zaoren Anshen capsule,while the treatment group was added wit h self-made prescription for replenishing qi,activating blood and tranquilizing spirit,after4 weeks of treatment,the therapeutic effects of the two groups were compared.Results:1.PSQI score: After treatment,the PSQI scores in both subjects decreased(p < 0.01).The decline in the treatment group was more significant than that in the reference grou p(p < 0.01).2.6MWT: 6MWT was significantly improved in both subjects after treatment(P<0.01).Increases in experimental group were remarkable in the reference group(P<0.01).3.Plasma NT-proBNP :Decreased obviously in both subjects after medication with plasma NT-pro BNP(P<0.01).The decline in the experimental group was more significant than that in the reference group(P<0.01).4.Cardiac function:After medication,the heart function of the two subjects were impr oved.The effective rate of cardiac function in the treatment group and the control group w ere 87.88% and 68.75% respectively.The effective rate in the treatment group was higher t han that in the control group(p < 0.05).5.TCM syndrome points: After medication,the total integral and all syndrome integ ral of the two groups were decreased.The decline in experimental group was more signi ficant than that in the reference group(P<0.01).And the total effective rate of the experi mental group(90.91%)was significantly higher than that of the reference group(71.88%)(p< 0.05).6.During the clinical trial observation,both groups of subjects were in a norma l range of safety indicators without adverse reactions,and the safety of this clinical trial was guaranteed.Research Conclusions:The curative effect of self-made prescription for replenishing qi,activating blood and calming mind combined with Western medicine on senile chronic heart failure with insomn ia(qi deficiency and blood stasis type)is better than Zaoren’an capsule in combination with western medicine.It effectively improves patient’s sleep,improves 6MWT,reduces plasma NT-pro BNP,improves heart function(NYHA),ensures safety and deserves further clinical research.