Analysis Of The Predictive Value Of NSE And CRP On Adverse Events After Vascular Intervention In Patients With ACI

Objective: The aim of this study is to assess the predictive power of neuron-specific enolase(NSE)and Creactive protein(CRP)in predicting adverse outcomes following vascular treatment in individuals with acute cerebral infarction(ACI).Methods: From September 1,2021 to December 1,2022 our hospital’s emergency department saw patients who had been diagnosed with acute cerebral infarction,and these were chosen and gathered for this study’s methods.After strict inclusion and exclusion criteria,118 patients with ACI who met the criteria were collected.The Modified Rankin Scale(m RS)was employed to separate patients suffering from ACI into two distinct categories.The prognosis for one group was positive(m RS greater than two points).The prognosis for the other group was dire: m RS >2 or death.The NIHSS of the National Institutes of Health classified the group into three distinct groups: mild(less than 5),moderate(5 points higher or equal to 20 points),and mild(less than 20 points).The baseline data at admission,preoperative and postoperative clinical laboratory examination data.Results: The good prognosis group had 82 patients,while the poor prognosis group had 36-the results being thus.No remarkable differences were noticed between the two sets in terms of sex ratio,smoking,drinking habits,medical history(hypertension,diabetes,coronary heart disease),heart rate,blood pressure and other indicators(P>0.05).A statistically significant difference(P<0.05)between the age and NIHSS scores of those in the poor prognosis group and those in the good prognosis group was observed,as well as a positive correlation between preoperative NSE and CRP.A correlation analysis revealed NIHSS scores in ACI patients to be significant(r=0.847,P<0.01).With the increase of NIHSS scores,the level of NSE before vascular intervention in ACI patients gradually increased(severe group vs moderate group vs mild group:23.85±4.35 vs 22.23±1.77 vs 18.03±2.04,P<0.01);preoperative CRP level also gradually increased(severe group vs moderate group vs mild group: 13.21±2.50 vs 9.84±2.23 vs 6.27±1.30,P<0.01).A statistically significant difference(P<0.05)was revealed by multivariate analysis between NSE(OR=1.085,95%CI:1.011～1.128,P<0.05)and CRP(OR=1.852,95%CI: 1.423～2.586,P<0.05).In the ACI group with a positive outlook,preoperative NSE and CRP levels were lower than those of the poor prognosis group(P<0.05).The optimal cut-off values of ROC curves NSE and CRP for predicting postoperative adverse events were21.67ng/m L and 8.39mg/L,respectively,and the AUC was 0.658(95% CI: 0.544～0.772)and 0.823(95%CI: 0.736～0.911),respectively,and the AUC for predicting adverse outcomes after vascular intervention in ACI patients was 0.849(95% CI: 0.774～0.924),respectively.Higher than detection of NSE and CRP alone.Conclusions:(1)This study showed that NSE and CRP were prognostic factors for adverse events after vascular intervention in ACI patients.(2)The detection of NSE and CRP has a good predictive value for adverse outcomes after vascular intervention in ACI patients.Combined testing may be more effective in diagnosing patients with ACI.(3)Clinical monitoring of NSE and CRP levels and reducing elevations of both may aid in screening and treatment of acute ischaemic stroke prognosis.