Expression And Clinical Significance Of PD-1/PD-L1 In Ovarian Epithelial Tumors

ObjectiveTo analyze the expression of programmed death receptor-1(PD-1)and its ligand programmed death ligand 1(PD-L1)in ovarian epithelial tumors,and to investigate its relationship with clinicopathologic features.MethodsA total of 80 paraffin tissue samples of ovarian tumor confirmed as epithelial ovarian tumor after surgical treatment in the Department of Gynecology,the First Affiliated Hospital of Dali University from June 2008 to September 2022 were selected and divided into three groups.Group A: ovarian malignant tumor(46 cases);Group B:borderline ovarian tumors(18 cases);Group C: ovarian benign tumors(16 cases).Then immunohistochemistry was used to detect the expression of PD-1 protein and PD-L1 protein in different ovarian epithelial tumor tissues,and statistical methods were combined to analyze the relationship between the expression levels of PD-1 and PD-L1 and various clinicopathological features,so as to explore their clinical significance.Results1.The expression of PD-1 protein increased in epithelial ovarian malignancies with a positive expression rate of 52.2%,and in borderline tumors and benign tumors with a positive rate of 33.3% and 12.5%,respectively.The positive expression rate of PD-1 was different between malignant tumors and benign tumors(P<0.0167),but there was no significant difference from the positive expression rate of borderline tumors(P>0.0167).2.The positive expression rate of PD-L1 protein was 73.9% in ovarian epithelial malignant tumors,which was significantly higher than that in borderline tumors(38.9%)and benign tumors(25.0%)(P<0.0167).With the increase of malignant degree of ovarian tumor,the positive expression rate of ovarian tumor showed a gradual increasing trend.3.The positive expression rate of PD-1 and PD-L1 protein in epithelial serous ovarian malignancies was significantly higher than that in non-serous ovarian malignancies(P<0.05).4.There were significant differences in the positive expression rate of PD-1 protein in ovarian epithelial malignant tumors with different FIGO pathological stages(P<0.05).The positive expression rate of PD-L1 protein in ovarian epithelial malignancies was different in different FIGO pathological stages,and also in different degrees of tumor differentiation and preoperative CA125 concentration(P<0.05).5.Spearman correlation analysis showed that the expression of PD-1 protein and PD-L1 protein was positively correlated in malignant epithelial ovarian tumors(rs=0.323,P<0.05).Conclusion1.The expression of PD-1 and PD-L1 increased in epithelial ovarian tumors,and the positive expression rate of PD-L1 increased with the increase of malignant degree of epithelial ovarian tumors.Moreover,PD-1 and PD-L1 were positively correlated with each other in epithelial ovarian malignancies.2.The expression levels of PD-1 and PD-L1 are higher in epithelial serous malignant ovarian tumors than in non-serous malignant ovarian tumors.3.The expression level of PD-1 was correlated with the FIGO stage of malignant epithelial ovarian tumors.The expression level of PD-L1 was correlated with FIGO stage,tumor differentiation and preoperative CA125 concentration of malignant epithelial ovarian tumors.4.The expression of PD-1 and PD-L1 is closely related to the occurrence,development and invasion of ovarian epithelial tumors,which can provide a new idea for the diagnosis and immunotherapy of epithelial ovarian cancer.