Correlation Study Between The Interleukin 8 And The Safety And Effect Of Benign Prostatic Hyperplasia Surgery

Objective:To explore the correlation between the concentration of interleukin-8 in prostatic fluid and the clinical indicators of benign prostatic hyperplasia,the safety and therapeutic effect of surgery,to provide new ideas for the diagnosis and treatment of BPH,and to provide a new clinical basis for the evaluation of surgical safety and prognosis.Methods:A total of 64 patients were diagnosed with benign prostatic hyperplasia and transurethral plasmakinetic resection of the prostate in the Department of Urology,Jianghan University Hospital from November 2021 to August 2022.The basic clinical data were collected according to the admission process,the serum prostate specific antigen,C reactive protein concentration and hemoglobin concentration were determined,the preoperative international prostate symptom score and quality of life score were evaluated,and the prostate volume,residual urine volume and the maximum preoperative urinary flow rate were determined.All patients,prostatic fluid was retained by prostate massage and the concentration of IL-8 was determined by enzyme-linked immunosorbent assay(ELISA).Indication for surgery and complete surgical treatment were diagnosed according to the guidelines for the diagnosis and treatment of prostatic hyperplasia.After the operation,the three-lumen catheter was detained for continuous bladder washing,stopped after the bladder rinse was clear,and the catheter was removed out after the urine was clear,observe the patient’s urination,whether the color was clear,whether urinary retention and urinary incontinence occurred.The maximum urinary flow rate was measured again 3 months after discharge,and the IPSS score and QOL score were evaluated.Obobserved indicators were recorded and statistical correlation and regression analysis were performed.Results:1.The concentration of IL-8 in prostatic fluid was significantly positively associated with bladder residual urine(r=0.83),serum C reactive protein concentration(r=0.61),IPSS score(r=0.75),QOL score(r=0.78),and previous urinary retention(r=0.77),it is most closely related to the maximum urinary flow rate(r=0.90)and has a negative correlation.It was significant associated with patient age(r=0.41)and serum PSA(r=0.60).The difference was statistically significant(p<0.001).Prostate volume(r=0.18)in BPH patients and IL-8 concentration in prostatic fluid were not closely correlated,and the difference was not statistically significant(p=0.150,p>0.05).2.The concentration of IL-8 in prostate fluid of BPH patients had a significant correlation with intraoperative bleeding(r=0.87)and postoperative bladder washing time(r=0.95),and with the operation time(r=0.67)and indwelling catheterization time(r=0.73),which were positively related.The difference was statistically significant(p<0.001).The concentration of prostatic fluid IL-8 was relatively high in patients who developed complications compared with patients without postoperative complications.3.The maximum urinary flow rate,IPSS score,and QOL score improved significantly after surgery,and the difference was statistically significant(p<0.001).The rate of maximum urinary flow rate(r=0.73)and QOL score(r=-0.76)correlated with IL-8 concentration in the prostate fluid,while it was moderately correlated with the rate of IPSS score(r=-0.38).The difference was statistically significant(p<0.001).The prostate fluid IL-8 concentration and the change rate of maximum urinary flow rate showed obvious positive correlation,significant negative correlation with the rate of change of QOL score and IPSS score,and the difference was statistically significant(p=0.002、p<0.001).Conclusions:A clear positive correlation between IL-8 concentration in prostatic fluid and preoperative bladder residual urine,C reactive protein concentration,PSA levels,IPSS scores,QOL scores,previous urinary retention,and intraoperative bleeding,operative time,time of postoperative bladder irrigation and indwelling catheterization in BPH patients.There was a clear negative correlation with the preoperative maximum urinary flow rate,postoperative IPSS score and QOL score change rate,and no significant correlation with the patient’s prostate volume.Suggesting that the elevated concentration of IL-8 in prostatic fluid may indicate greater clinical symptoms in BPH patients,and that surgical safety and surgical efficacy may not be as expected.Therefore,IL-8 has the potential to provide a non-invasive test for the diagnosis and treatment of BPH,and to provide a new and reliable clinical basis for the selection of treatment modalities and the evaluation of the prognosis of BPH patients.