Analysis Of Influencing Factors Of Functional Constipation And Correlation Between Clinical Symptoms And Colonic Transit Test

Objective:This study was to analyze the influencing factors of functional constipation(FC),to classify FC patients by colonic transit test and to explore the correlation between clinical symptoms and constipation classification,so as to provide reference for diagnosis and individualized treatment.Methods:40 patients who were diagnosed as functional constipation according to Rome IV diagnostic criteria and completed colonic transit test in the affiliated hospital of Inner Mongolia medical university(including outpatient and inpatient)from November 2021 to February 2023 were selected as FC group,and 40 healthy people matched in age and sex who were treated in the physical examination center of our hospital during the same period were selected as control group.The relevant clinical data of FC group and control group were collected in the form of questionnaire.The collection contents of FC group included:1.Basic information: name,age,gender,telephone number;2.Influencing factors:residence,education level,water intake,fruit intake,spicy food intake,type of diet,length of sleep,amount of exercise,defecation posture,whether defecation is inhibited and whether there is family history;3.Symptoms of bowel movements include:defecation effort,defecation incomplete feeling,defecation blockage feeling,manual assisted defecation,stool character Bristol classification,spontaneous defecation less than 3 times/week;Healthy control group only need to collect the above basic information and influencing factors.FC group patients need to undergo colonic transit test,clear constipation classification,avoid the use of laxatives and prokinetic drugs during the examination,and monitor the symptoms and signs of patients,statistics of adverse events,all collected clinical data and the establishment of a corresponding database,analysis of FC influencing factors,comparison of FC patients with clinical symptoms and colonic transit test classification correlation.Results:1.A total of 80 questionnaires(FC group:40,control group:40);The mean age of FC group was 51.55±14.231 years old,and that of control group was 49.55±15.021 years old.There was no significant difference in age between the two groups(P>0.05).There were 27(33.8%)males and 53(66.2%)females,the ratio of male to female was 0.51:1.The positive rate of FC in females was 52.8% and that in males was 44.4%,the difference was not statistically significant(P>0.05);2.The results of single factor analysis showed that:There were significant differences in spicy food intake,fruit intake,water intake and defecation inhibition(P<0.05).There was no significant difference in the type of residence,diet,defecation posture,family history of constipation,exercise frequency and sleep duration between the two groups(P>0.05);3.The significant influencing factors of univariate analysis were included in Logistic multivariate regression analysis.The results showed that:The intake of spicy food was higher(OR=24.259,95%CI:3.506-167.871),inhibition of defecation(OR=15.586,95%CI:2.859-84.962)was a risk factor for functional constipation,and drinking more water(OR=0.110,95%CI:0.023-0.519),more fruit intake(OR=0.163,95%CI:0.028-0.950)was the protective factor of functional constipation;4.40 FC patients underwent colonic transit test,During the test,no adverse reactions occurred after taking gastrointestinal marker capsules,No abnormal routine biochemical indicators were found during the visit,and no adverse events occurred;5.Colonic transit test typing results showed:Normal transit type was 50.0%(20cases),slow transit type was 27.5%(11 cases),outlet obstruction type was 22.5%(9 cases),no mixed type was found;6.The distribution of clinical symptoms in FC patients showed that the number of defecation decreased by 100%Among the 40 patients with FC,35 patients(87.5%)had dry stools(Bristol type 1 and 2),29 patients(72.5%)had difficulty in defecating,24patients(60%)had incomplete defecation,20 patients(50%)had obstruction in defecation,and9 patients(22.5%)had manual defecation;7.The relationship between clinical symptoms and constipation types suggested that:The diagnosis of OOC in the group requiring manual defecation was significantly higher than that in the group not requiring manual defecation(P<0.05),and the difference between the two groups was statistically significant.Spearman correlation coefficient was further used to evaluate the correlation between manual defecation and OOC(rs=0.473,P=0.002),suggesting that the patients requiring manual defecation were more likely to be diagnosed as OOC,There was no statistical difference between the other defecation symptoms and constipation types.Conclusion:1.Functional constipation patients with bad habits such as eating spicy food,inhibition of defecation may aggravate the secret;drinking more water,eating more fruits and other foods rich in dietary fiber can effectively improve constipation;2.Colonic transit test plays an important role in the diagnosis of constipation,Normal transit type is the most common type in clinic,and this test has the advantages of simple,high safety and can be widely used in clinic;3.The most common clinical symptoms of patients with functional constipation are decreased defecation frequency and dry stool,Patients who need manual assistance are more likely to be diagnosed as outlet obstructive constipation,but they still need to be further confirmed by relevant examinations.